136468-36-5
136468-36-5 structure
- Name: Foropafant
- Chemical Name: N,N-dimethyl-N'-(pyridin-3-ylmethyl)-N'-[4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl]ethane-1,2-diamine
- CAS Number: 136468-36-5
- Molecular Formula: C28H40N4S
- Molecular Weight: 464.70900
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-02-18 08:00:00
- Modify Date: 2025-08-25 10:48:15
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Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1].
| Name | N,N-dimethyl-N'-(pyridin-3-ylmethyl)-N'-[4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl]ethane-1,2-diamine |
|---|---|
| Synonyms | MFCD00904759 |
| Description | Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. |
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| Related Catalog | |
| Target |
Ki: 57 pM ([3H]PAF binding)[1] |
| References |
| Density | 1.065g/cm3 |
|---|---|
| Boiling Point | 571.6ºC at 760mmHg |
| Molecular Formula | C28H40N4S |
| Molecular Weight | 464.70900 |
| Flash Point | 299.5ºC |
| Exact Mass | 464.29700 |
| PSA | 60.50000 |
| LogP | 7.14350 |
| Vapour Pressure | 4.49E-13mmHg at 25°C |
| Index of Refraction | 1.575 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |