Foropafant
Foropafant structure
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Common Name | Foropafant | ||
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| CAS Number | 136468-36-5 | Molecular Weight | 464.70900 | |
| Density | 1.065g/cm3 | Boiling Point | 571.6ºC at 760mmHg | |
| Molecular Formula | C28H40N4S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 299.5ºC | |
Use of ForopafantForopafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. |
| Name | N,N-dimethyl-N'-(pyridin-3-ylmethyl)-N'-[4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl]ethane-1,2-diamine |
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| Synonym | More Synonyms |
| Description | Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. |
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| Related Catalog | |
| Target |
Ki: 57 pM ([3H]PAF binding)[1] |
| References |
| Density | 1.065g/cm3 |
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| Boiling Point | 571.6ºC at 760mmHg |
| Molecular Formula | C28H40N4S |
| Molecular Weight | 464.70900 |
| Flash Point | 299.5ºC |
| Exact Mass | 464.29700 |
| PSA | 60.50000 |
| LogP | 7.14350 |
| Vapour Pressure | 4.49E-13mmHg at 25°C |
| Index of Refraction | 1.575 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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Platelet-activating factor (PAF) is not an essential component of the cascade leading to smooth muscle cell proliferation following vascular injury.
J. Lipid Mediat. Cell Signal. 12(1) , 49-57, (1995) In order to evaluate the relative importance platelet-activating factor (PAF) in the proliferative process leading to restenosis, the effect of SR 27417, a novel highly potent PAF receptor antagonist,... |
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Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine.
Arzneimittelforschung 46(4) , 407-12, (1996) SR 27417 (CAS 136468-36-5, N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisop ropylphenyl) thiazol-2-yl]amine), a highly potent platelet-activating factor (PAF) receptor antagonist, was t... |
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Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin.
Proc. Natl. Acad. Sci. U. S. A. 91(20) , 9655-8, (1994) With the recent heightened concern about cholera around the world come new questions about the mechanism by which cholera toxin causes diarrhea. Peterson and Ochoa have suggested that prostaglandin sy... |
| MFCD00904759 |