80879-63-6
80879-63-6 structure
- Name: EMIGLITATE
- Chemical Name: ethyl 4-[2-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy]benzoate
- CAS Number: 80879-63-6
- Molecular Formula: C17H25NO7
- Molecular Weight: 355.38300
- Catalog: API Hormone and endocrine-regulating drugs Pancreatic hormones and other blood sugar regulating drugs
- Create Date: 2018-06-17 16:07:48
- Modify Date: 2024-01-19 16:25:11
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Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase.
| Name | ethyl 4-[2-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy]benzoate |
|---|---|
| Synonyms |
Ethyl p-(2-((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidino)ethoxy)benzoate
ethyl 4-{2-[(2r,3r,4r,5s)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy}benzoate EINECS 279-613-2 1,5-Dideoxy-1,5-((2-(4-(ethoxycarbonyl)phenoxy)ethyl)imino)-D-glucitol Emiglitatum [Latin] Emiglitato [Spanish] Bay-o-1248 Emiglitate |
| Description | Emiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase. |
|---|---|
| Related Catalog | |
| In Vitro | Emiglitate greatly suppresses the glucose-stimulated insulin release in parallel with an inhibitory effect on the activities of acid glucan-1,4-α-glucosidase and acid α-glucosidase. In contrast, the activities of acid phosphatase and N-acetyl-β-D-glucosaminidase tend to increase in the presence of the α-glucoside hydrolase inhibitor. The CO-induced amplification of the glucose-stimulated insulin release as well as of the increased activities of the acid α-glucoside hydrolases are abrogated by emiglitate and displayed the same levels as in the absence of CO. The CO-induced rise in the activities of acid phosphatase and acid N-acetyl-β-D-glucosaminidase is not appreciably affected by emiglitate[1]. |
| In Vivo | In fasted rats, emiglitate inducec a significant, dose-dependent increase of hepatic glycogen concentrations. The increase in hepatic glycogen is due to lysosomal storage of glycogen only. Emiglitate in the amount of 5 mg/kg b.wt. does not induce significant changes either of glycogen concentrations or at the EM-level[2]. |
| Kinase Assay | Effect of the selective α-glucoside hydrolase inhibitor emiglitate (100 μM) on glucose-stimulated insulin secretion and islet lysosomal enzyme activities at 12 mM glucose in the absence and presence of CO gas is studied. Islets are incubated in the absence (open columns) or presence (solid columns) of emiglitate. Experiments are performed both in the presence (the two columns to the right) and in the absence (the two columns to the left) of exogenous CO[1]. |
| References |
| Density | 1.328g/cm3 |
|---|---|
| Boiling Point | 580.2ºC at 760 mmHg |
| Molecular Formula | C17H25NO7 |
| Molecular Weight | 355.38300 |
| Flash Point | 304.7ºC |
| Exact Mass | 355.16300 |
| PSA | 119.69000 |
| Index of Refraction | 1.584 |
| Storage condition | 2-8℃ |