Name | (-)-α-thujone |
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Synonyms |
Thujon
l-Thujone Tanacetone 6-Ketosabinane Bicyclo[3.1.0]hexan-3-one,4-methyl-1-(1-methylethyl)-, (1S,4R,5R)- (-)-alpha-thujone |
Description | α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier[1][2][3]. |
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Related Catalog | |
References |
Density | 0.914 g/mL at 20ºC(lit.) |
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Boiling Point | 84-86ºC17 mm Hg(lit.) |
Melting Point | 181ºC |
Molecular Formula | C10H16O |
Molecular Weight | 152.23300 |
Flash Point | 148 °F |
Exact Mass | 152.12000 |
PSA | 17.07000 |
LogP | 2.25760 |
Index of Refraction | n20/D 1.450 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
Risk Phrases | R22 |
Safety Phrases | 23-26-36/37/39-45 |
RIDADR | UN 2810 6.1/PG 3 |
RTECS | XO9625000 |