132376-92-2

132376-92-2 structure

Name: Thymidine-d2
Chemical Name: [5',5''-2h2]thymidine
CAS Number: 132376-92-2
Molecular Formula: C₁₀H₁₂D₂N₂O₅
Molecular Weight: 244.24100
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-04-01 06:28:41
Modify Date: 2024-01-04 06:30:38
Thymidine-d2 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1

Name	[5',5''-2h2]thymidine
Synonyms	diethyl 3,3'-diethyl-4,4'-dimethyl-2,2'-dipyrrylmethane-5,5'-dicarboxylate diethyl 3,3'-diethyl-4,4'-dimethyl-2,2'-dipyrromethane-5,5'-dicaboxylate

Description	Thymidine-d2 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17).;FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4

3544-99-8

~71%

132376-92-2

Precursor 1
3544-99-8
DownStream 0