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135410-20-7

135410-20-7 structure
135410-20-7 structure
  • Name: Acetamiprid
  • Chemical Name: (E)-acetamiprid
  • CAS Number: 135410-20-7
  • Molecular Formula: C10H11ClN4
  • Molecular Weight: 222.674
  • Catalog: Chemical pesticide Insecticide Organochlorine insecticide
  • Create Date: 2018-02-08 08:00:00
  • Modify Date: 2024-01-02 17:38:34
  • Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders[1][2].

Name (E)-acetamiprid
Synonyms (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N’-cyano-N-methylethanimidamide
(E)-N-[(6-Chloropyridin-3-yl)methyl]-N'-cyano-N-methylacetimidamide
(E)-N1-[(6-Chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine
(E)-N-((6-Chloropyridin-3-yl)methyl)-N'-cyano-N-methylacetimidamide
acetamiprid
(1E)-N-[(6-Chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide
(E)-N-(6-Chloro-3-pyridylmethyl)-N'-cyano-N-methylacetamidine
(E)-N-[(6-Chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide
Ethanimidamide, N-[(6-chloro-3-pyridinyl)methyl]-N'-cyano-N-methyl-, (1E)-
(1E)-N-[(6-chloropyridin-3-yl)methyl]-N’-cyano-N-methylethanimidamide
N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide
MFCD06201842
(1E)-N-[(6-Chlorpyridin-3-yl)methyl]-N'-cyan-N-methylethanimidamid
T6NJ BG E1N1Y1&UNCN &&E Form
(1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide
Description Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders[1][2].
Related Catalog
Target

nAChR[1]

In Vivo Acetamiprid decreases in body weight and mildly affected spermatogenesis. [1]. Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice[1]. Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats[2]. Animal Model: Male Sprague Dawley (SD) rats[2] Dosage: 10 mg/kg, 30 mg/kg Administration: Oral gavage; daily; for 35 days Result: Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.
References

[1]. Terayama H, et al. Effect of acetamiprid on the immature murine testes. Int J Environ Health Res. 2018 Dec;28(6):683-696.

[2]. Kong D, et al. Acetamiprid inhibits testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells. Biol Reprod. 2017 Jan 1;96(1):254-265.

Density 1.2±0.1 g/cm3
Boiling Point 352.4±52.0 °C at 760 mmHg
Melting Point 101-103ºC
Molecular Formula C10H11ClN4
Molecular Weight 222.674
Flash Point 166.9±30.7 °C
Exact Mass 222.067230
PSA 52.28000
LogP 0.62
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.571
Storage condition 0-6°C
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H330-H412
Precautionary Statements P260-P273-P284-P301 + P310-P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases R23/25;R57
Safety Phrases S45
RIDADR UN 2811
RTECS KJ4235200
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933399022
HS Code 2933399022
Summary 2933399022 1,1'-dimethyl-[4,4'-bipyridine]-1,1'-diium。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%