144-90-1

144-90-1 structure

Name: 3-Aminoisobutanoic acid
Chemical Name: DL-3-Aminoisobutyric acid DL-3-Aminoisobutyric acid
CAS Number: 144-90-1
Molecular Formula: C₄H₉NO₂
Molecular Weight: 103.120
Catalog: Biochemical Amino acids and their derivatives Other amino acid derivatives
Create Date: 2018-07-12 15:28:54
Modify Date: 2024-01-08 11:55:55
3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Name	DL-3-Aminoisobutyric acid DL-3-Aminoisobutyric acid
Synonyms	L-3-amino-isobutyric acid D-3-Amino-2-methylpropanoic acid EINECS 205-644-8 Propanoic acid, 3-amino-2-methyl- D-3-Amino-2-methylpropionic acid (-)-β-Aminoisobutyric acid D-2-methyl-b-Alanine b-Aminoisobutyric acid (±)-b-Aminoisobutyric acid 2-Methyl-b-alanine 3-Amino-2-methylpropanoic acid 3-Aminoisobutyric Acid D-b-Aminoisobutyric acid DL-3-Aminoisobutyric Acid DL-2-Methyl-b-alanine L-3-amino-isobutanoic acid UNII:T68ALE2O9F L-3-aminoisobutyric acid 3-amino-2-methyl-propioinic acid (-)-b-Aminoisobutyric acid MFCD00008145

Description	3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vivo	Weight is slightly decreased in the mice by the end of 3-Amino-2-methylpropanoic acid (BAIBA) treatment. Analysis of body composition using MRI demonstrates BAIBA treatment significantly decreases body fat in the mice. Consistent with the effects on thermogenic and β-oxidation gene expression and body weights, analysis with metabolic cages indicates that oxygen consumption (VO2) and whole body energy expenditure are increased in the BAIBA treated mice without any significant difference in activity or food intake. The mice are also challenged with an intraperitoneal glucose tolerance test (IPGTT). BAIBA is found to significantly improve the glucose tolerance in the mice as determined by the area under the curve of the IPGTT[1].
Animal Admin	Mice[1]Six week old mice are either treated with 3-Amino-2-methylpropanoic acid (BAIBA:100 mg/kg/day) or remains untreated (control mice). Their weights are monitored weekly[1].
References	[1]. Roberts LD, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 7;19(1):96-108.

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