1116571-01-7
1116571-01-7 structure
- Name: LIMK-IN-22j
- Chemical Name: (2S)-N-(3-Bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1-piperazinecarboximidamide
- CAS Number: 1116571-01-7
- Molecular Formula: C20H21BrN8
- Molecular Weight: 453.34
- Catalog: Signaling Pathways Cell Cycle/DNA Damage LIM Kinase (LIMK)
- Create Date: 2016-10-31 17:57:56
- Modify Date: 2024-01-29 15:50:28
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LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research[1].
| Name | (2S)-N-(3-Bromophenyl)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2 ,3-d]pyrimidin-4-yl)-1-piperazinecarboximidamide |
|---|---|
| Synonyms | LIMK-IN-22j |
| Description | LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research[1]. |
|---|---|
| Related Catalog | |
| Target |
LIMK1:0.9 nM (IC50) LIMK2:0.5 nM (IC50) ROCK1:260 nM (IC50) ROCK2:2700 nM (IC50) |
| References |
| Molecular Formula | C20H21BrN8 |
|---|---|
| Molecular Weight | 453.34 |
| Exact Mass | 452.10700 |
| PSA | 96.23000 |
| LogP | 3.56438 |
| Hazard Codes | Xn |
|---|
|
~58%
1116571-01-7 |
| Literature: US2009/42893 A1, ; Page/Page column 9; 10 ; US 20090042893 A1 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |