92933-48-7

92933-48-7 structure

Name: LUF 6283
Chemical Name: 5-Butyl-1H-pyrazole-3-carboxylic acid
CAS Number: 92933-48-7
Molecular Formula: C₈H₁₂N₂O₂
Molecular Weight: 168.19300
Catalog: Signaling Pathways Cell Cycle/DNA Damage PERK
Create Date: 2016-01-06 03:16:02
Modify Date: 2024-01-04 08:09:45
LUF6283 is a potent and orally active HCA(2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect[1].

Name	5-Butyl-1H-pyrazole-3-carboxylic acid
Synonyms	5-butyl-[1,3,5]triazinane-2-thione Dihydrokainic acid 5-Butyl-1(2)H-pyrazol-3-carbonsaeure 5-Butyl-tetrahydro-s-triazin-2(1H)-thion 5-butyl-1,4,5,6-tetrahydro-1,3,5-triazine-2-thiol 1-Butyl-hexahydrotriazinthion-4 5-butyl-1(2)H-pyrazole-3-carboxylic acid

Description	LUF6283 is a potent and orally active HCA(2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PERK
Target	EC50: 0.32 ± 0.06 μM (pERK1/2)[1]
In Vivo	LUF6283 (C57BL/6 mice, 400 mg/kg, Oral gavage, once a day for 4 weeks) has no effect on adipose tissue ATGL/HSL expression, and significantly reduces the expression of apolipoprotein B (APOB)[1].
References	[1]. Li Z, et al. Effects of pyrazole partial agonists on HCA(2) -mediated flushing and VLDL-triglyceride levels in mice. Br J Pharmacol. 2012 Oct;167(4):818-25.

RIDADR	NONH for all modes of transport

72894-00-9

~69%

92933-48-7

Literature: Seki; Isegawa; Fukuda; Ohki Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1568 - 1577

591-78-6

92933-48-7

60415-21-6

92933-48-7

Literature: Lehninger Journal of Biological Chemistry, 1944 , vol. 153, p. 564

102540-71-6

92933-48-7

Literature: Lehninger Journal of Biological Chemistry, 1944 , vol. 153, p. 564