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97-05-2

97-05-2 structure
97-05-2 structure
  • Name: Sulfosalicylic Acid
  • Chemical Name: 5-Sulfosalicylic acid
  • CAS Number: 97-05-2
  • Molecular Formula: C7H6O6S
  • Molecular Weight: 218.184
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Dopamine β-hydroxylase
  • Create Date: 2018-07-10 17:46:40
  • Modify Date: 2024-01-02 19:21:56
  • 5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell line, MCF-7, with less toxicity[1]. 5-Sulfosalicylic acid has antioxidant activities[2].

Name 5-Sulfosalicylic acid
Synonyms Sulfosalicylic Acid
5-Sulfosalicylic Acid
EINECS 202-555-6
MFCD00007508
Benzoic acid, 2-hydroxy-5-sulfo-
Sulphosalicylic acid
2-Hydroxy-5-sulfobenzoic acid
Description 5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell line, MCF-7, with less toxicity[1]. 5-Sulfosalicylic acid has antioxidant activities[2].
Related Catalog
In Vitro 5-Sulfosalicylic acid (0.5-4 mM, 24 h) shows a reduction in the viability of MCF-7 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF-7 and HUVEC cells Concentration: 0.5, 1, 2, 4 mM Incubation Time: 24 hours Result: Showed the viability of 63.3% and 70.4% in MCF-7 and HUVEC control cells respectively at 1 mM 5-Sulfosalicylic acid.
References

[1]. Münteha Özsoy, et al. A protein-sulfosalicylic acid/boswellic acids @metal-organic framework nanocomposite as anticancer drug delivery system. Colloids Surf B Biointerfaces. 2021 Aug;204:111788.

[2]. K. Ezhilmathi, et al. Effect of 5-sulfosalicylic acid on antioxidant activity in relation to vase life of Gladiolus cut flowers. Plant Growth Regul 51, 99 (2007).

Density 1.8±0.1 g/cm3
Melting Point 120°C
Molecular Formula C7H6O6S
Molecular Weight 218.184
Exact Mass 217.988510
PSA 120.28000
LogP -0.69
Index of Refraction 1.650

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VO6500000
CHEMICAL NAME :
Salicylic acid, 5-sulfo-
CAS REGISTRY NUMBER :
97-05-2
BEILSTEIN REFERENCE NO. :
0650741
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C7-H6-O6-S
MOLECULAR WEIGHT :
218.19
WISWESSER LINE NOTATION :
WSQR DQ CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1850 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570587
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,565,1969
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
7940 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570587 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81215 No. of Facilities: 2580 (estimated) No. of Industries: 7 No. of Occupations: 10 No. of Employees: 18777 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81215 No. of Facilities: 1425 (estimated) No. of Industries: 4 No. of Occupations: 16 No. of Employees: 44936 (estimated) No. of Female Employees: 36255 (estimated)
Hazard Codes Xn
Risk Phrases R22;R36/37/38
Safety Phrases S26
RIDADR UN 1760
Packaging Group III
Hazard Class 8
HS Code 2918290000

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Literature: Chemicke Listy, , vol. 32, p. 292 Chem. Zentralbl., , vol. 110, # I p. 795

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Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 61, p. 545

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Literature: Gazzetta Chimica Italiana, , vol. 18, p. 346,351

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Literature: Monatshefte fuer Chemie, , vol. 18, p. 124

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Literature: Journal of the Indian Chemical Society, , vol. 5, p. 437 Chem. Zentralbl., , vol. 99, # II p. 2241

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Literature: Journal of the Indian Chemical Society, , vol. 5, p. 437 Chem. Zentralbl., , vol. 99, # II p. 2241

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Literature: Justus Liebigs Annalen der Chemie, , vol. 179, p. 107 Chemische Berichte, , vol. 33, p. 3238

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Literature: Am.ch., vol. <10>14, p. 193

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Literature: Justus Liebigs Annalen der Chemie, , vol. 103, p. 45,50
HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%