96964-90-8

96964-90-8 structure

Name: 2′-Deoxy-8-(phenylmethoxy)guanosine
Chemical Name: 2-amino-9-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-phenylmethoxy-3H-purin-6-one
CAS Number: 96964-90-8
Molecular Formula: C₁₇H₁₉N₅O₅
Molecular Weight: 373.36
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-08-26 09:14:48
Modify Date: 2024-01-14 16:36:15
2′-Deoxy-8-(phenylmethoxy)guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2-amino-9-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-phenylmethoxy-3H-purin-6-one
Synonyms	8-Benzyloxy-2'-deoxyguanosine 2'-Deoxy-8-(phenylmethoxy)guanosine

Description	2′-Deoxy-8-(phenylmethoxy)guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

13389-03-2

100-51-6

~82%

96964-90-8

Literature: Nampalli, Satyam; Kumar, Shiv Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1677 - 1679

67-68-5

13389-03-2

~78%

96964-90-8

Literature: Nampalli, Satyam; Livshin, Inna; Kumar, Shiv Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 697 - 699

13389-03-2

20194-18-7

96964-90-8

Literature: Varaprasad, Chamakura V.; Bulychev, Nickolai; Grollman, Arthur P.; Johnson, Francis Tetrahedron Letters, 1996 , vol. 37, # 1 p. 9 - 12

961-07-9

96964-90-8

Literature: Kannan, Arunkumar; Burrows, Cynthia J. Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 720 - 723