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153871-75-1

153871-75-1 structure
153871-75-1 structure
  • Name: carboxyebselen
  • Chemical Name: 4-(3-oxo-1,2-benzoselenazol-2-yl)benzoic acid
  • CAS Number: 153871-75-1
  • Molecular Formula: C14H9NO3Se
  • Molecular Weight: 318.18600
  • Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
  • Create Date: 2017-11-07 18:23:00
  • Modify Date: 2024-02-03 11:57:30
  • Carboxyebselen (HOOC-Ebs) is a potent and selective inhibitor of endothelial nitric oxide synthase (eNOS)[1].

Name 4-(3-oxo-1,2-benzoselenazol-2-yl)benzoic acid
Synonyms 4-(3-Oxo-1,2-benzoselenazol-2(3H)-yl)benzoic acid
Carboxyebselen
4-(1,2-benzisoselenazol-3-(2H)-one-2-yl)benzoic acid
Hooc-ebs
Benzoic acid,4-(3-oxo-1,2-benzisoselenazol-2(3H)-yl)
2-(carboxyphenyl)-1,2-benzisoselenazol-3(2H)-one
4-(2,3-dihydro-3-oxo-1,2-benzisoselenazol-2-yl)benzoic acid
Description Carboxyebselen (HOOC-Ebs) is a potent and selective inhibitor of endothelial nitric oxide synthase (eNOS)[1].
Related Catalog
In Vivo Carboxyebselen (HOOC-Ebs), a derivative of Ebselen (Ebs) inhibits NOS present in enzymatic preparations from bovine endothelium, porcine cerebella, and murine spleen, however, it is both more potent and more selective for the constitutive endothelial NOS than Ebs. Unlike Ebs, HOOC-Ebs (0.1-30 microM) causes a concentration-dependent endothelium-independent relaxations of rings of rabbit aorta[1].
References

[1]. Hatchett RJ, et al. Carboxyebselen a potent and selective inhibitor of endothelial nitric oxide synthase. J Physiol Pharmacol. 1994;45(1):55-67.

Boiling Point 531.5ºC at 760mmHg
Molecular Formula C14H9NO3Se
Molecular Weight 318.18600
Flash Point 275.3ºC
Exact Mass 318.97500
PSA 59.30000
LogP 1.74590
Vapour Pressure 3.96E-12mmHg at 25°C