149676-40-4
149676-40-4 structure
- Name: Pefloxacin mesylate dihydrate
- Chemical Name: Pefloxacin mesylate dihydrate
- CAS Number: 149676-40-4
- Molecular Formula: C18H28FN3O8S
- Molecular Weight: 465.49400
- Catalog: API Synthetic anti-infective drugs Quinolone
- Create Date: 2018-06-28 16:41:23
- Modify Date: 2026-07-01 12:31:09
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Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse)Target: DNA gyrasePefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections. Pefloxacin is commonly referred to as afluoroquinolone (or quinolone) drug and is a member of the fluoroquinolone class of antibacterials. It is an analog of norfloxacin. It is a synthetic fluoroquinolone, belonging to the 3rd generation of quinolones. Pefloxacin is extensively prescribed in France. Pefloxacin has not been approved for use in the United States.The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.
| Name | Pefloxacin mesylate dihydrate |
|---|---|
| Synonyms |
MFCD01685696
Pefloxacin Mesylate dihydra 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid,dihydrate 3-Quinolinecboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate EINECS 274-613-9 Pefloxacin dihydrate mesylate PEFLOXACIN METHANESULFONATE EU-5306 RB-1589 1-Ethyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-cboxylic acid compound with methanesulfonic acid hydrate Pefloxacine monomethanesulfonate dihydrate, Pefloxacinium methanesulfonate dihydrate, 3-Quinolinecboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate Pefloxacin mesilate dihydrate 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-Quinolinecboxylic acid methanesulfonate hydrate (1:1:2) PERFLOXACINE 3-Quinolinecboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-Methyl-1-piperazinyl)-4-oxo-, Methanesulfonate, hydrate (1:1:2) Pefloxacin mesylate`Pefloxacin mesylate dihydrate Pefloxacin dihydrate methanesulfonate Pefloxacin (mesylate hydrate) /1-Ethyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinolin-3-cboxylic acid compound with methanesulfonic acid (1:1 Pefloxacine monomethanesulfonate dihydrate 1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid mesylate dihydrate Pefloxacin mesylate dihydrdate PEFLOXACINE METHANSULFONATE DIHYDRATE PEFLOXACINE MESYLATE DIHYDRATE 1-ETHYL-6-FLUORO-1,4-DIHYDRO-7-(4-METHYL-1-PIPERAZINYL-4-OXO-3-QUINOLINE CBOXYLIC ACID) METHANE SULPHONATE DIHYDRATE Pefloxacinium methanesulfonate dihydrate 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CBOXYLIC ACID //BP Pefloxacinium mesylate dihydrate Pefloxacin for system suitability CRS 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid compound with methanesulfonic acid (1:1) hydrate /1-ethyl-6-fluoro-7-(4-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid coMpound with Methanesulfonic acid (1:1 Pefloxacin Mesylate Dihydrate, 10 mM in DMSO PEFLOXACIN MESYLATE DIHYDRATE 3-Quinolinecarboxylic acid (1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo PEFLOXACIN METHANE SULFONATE DIHYDRATE |
| Description | Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse)Target: DNA gyrasePefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections. Pefloxacin is commonly referred to as afluoroquinolone (or quinolone) drug and is a member of the fluoroquinolone class of antibacterials. It is an analog of norfloxacin. It is a synthetic fluoroquinolone, belonging to the 3rd generation of quinolones. Pefloxacin is extensively prescribed in France. Pefloxacin has not been approved for use in the United States.The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited. |
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| Related Catalog | |
| References |
| Boiling Point | 529.1ºC at 760mmHg |
|---|---|
| Melting Point | 271ºC |
| Molecular Formula | C18H28FN3O8S |
| Molecular Weight | 465.49400 |
| Flash Point | 273.8ºC |
| Exact Mass | 465.15800 |
| PSA | 146.99000 |
| LogP | 2.06960 |
| Storage condition | Store at?0-5°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22-36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| RTECS | VB2002200 |