149676-40-4

• 常用中文名：培氟沙星
• 常用英文名：Pefloxacin mesylate dihydrate
• CAS号：149676-40-4
• 分子式：C₁₈H₂₈FN₃O₈S
• 分子量：465.49400
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-06-28 16:41:23
• 更新时间：2026-07-01 12:31:09
• 去水甲磺酸Pefloxacin是抗菌素,能通过抑制DNA旋转酶阻断细菌DNA复制。

名称

• 中文名: 培氟沙星
• 英文名: Pefloxacin mesylate dihydrate
• 中文别名: 1-乙基-6-氟-7-(4-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-甲酸,甲磺酸,水(1:1:2); 甲烷磺酸培氟沙星二水合物; 甲磺酸培氟沙星水合物; 培氟沙星甲磺酸盐标准品; 甲磺酸培氟沙星二水; 培氟沙星二水甲磺酸盐(培氟沙星杂质1); 培氟沙星/Pefloxacin mesylate dihydrate; 1-乙基-6-氟-7-(4-甲基哌嗪-1-基)-4-氧代喹啉-3-羧酸; 甲磺酸培氟沙星二水合物,10 MM DMSO 溶液; Pefloxacin Mesylate Dihydrate 甲磺酸培氟沙星二水合物; 甲磺酸培氟沙星二水合物; 1-乙基-6-氟-7-(4-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-甲酸甲磺酸盐二水合物; 1-乙基-6-氟-7-(4-甲基哌嗪基)-4-氧代-1,4-二氢喹啉-3-羧酸甲磺酸盐; 盐酸地布卡因; 培氟沙星二水甲磺酸盐; 甲磺酸培氟沙星(标准品)
• 英文别名: MFCD01685696; Pefloxacin Mesylate dihydra; 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid,dihydrate; 3-Quinolinecboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate; EINECS 274-613-9; Pefloxacin dihydrate mesylate; PEFLOXACIN METHANESULFONATE; EU-5306; RB-1589; 1-Ethyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-cboxylic acid compound with methanesulfonic acid hydrate; Pefloxacine monomethanesulfonate dihydrate, Pefloxacinium methanesulfonate dihydrate, 3-Quinolinecboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate; Pefloxacin mesilate dihydrate; 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-Quinolinecboxylic acid methanesulfonate hydrate (1:1:2); PERFLOXACINE; 3-Quinolinecboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-Methyl-1-piperazinyl)-4-oxo-, Methanesulfonate, hydrate (1:1:2); Pefloxacin mesylate`Pefloxacin mesylate dihydrate; Pefloxacin dihydrate methanesulfonate; Pefloxacin (mesylate hydrate); /1-Ethyl-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinolin-3-cboxylic acid compound with methanesulfonic acid (1:1; Pefloxacine monomethanesulfonate dihydrate; 1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid mesylate dihydrate; Pefloxacin mesylate dihydrdate; PEFLOXACINE METHANSULFONATE DIHYDRATE; PEFLOXACINE MESYLATE DIHYDRATE; 1-ETHYL-6-FLUORO-1,4-DIHYDRO-7-(4-METHYL-1-PIPERAZINYL-4-OXO-3-QUINOLINE CBOXYLIC ACID) METHANE SULPHONATE DIHYDRATE; Pefloxacinium methanesulfonate dihydrate; 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CBOXYLIC ACID //BP; Pefloxacinium mesylate dihydrate; Pefloxacin for system suitability CRS; 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid compound with methanesulfonic acid (1:1) hydrate; /1-ethyl-6-fluoro-7-(4-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid coMpound with Methanesulfonic acid (1:1; Pefloxacin Mesylate Dihydrate, 10 mM in DMSO; PEFLOXACIN MESYLATE DIHYDRATE; 3-Quinolinecarboxylic acid (1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo; PEFLOXACIN METHANE SULFONATE DIHYDRATE

物化性质

• 沸点: 529.1ºC at 760mmHg
• 熔点: 271ºC
• 分子式: C₁₈H₂₈FN₃O₈S
• 分子量: 465.49400
• 闪点: 273.8ºC
• 精确质量: 465.15800
• PSA: 146.99000
• LogP: 2.06960
• 外观性状: 白色 粉末
• 储存条件: Store at?0-5°C

生物活性

• 描述: 去水甲磺酸Pefloxacin是抗菌素,能通过抑制DNA旋转酶阻断细菌DNA复制。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.

  [2]. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H319
• 警示性声明: P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22-36
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• RTECS号: VB2002200