16265-56-8

16265-56-8 structure

Name: 6-deoxyjacareubin
Chemical Name: 5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one
CAS Number: 16265-56-8
Molecular Formula: C₁₈H₁₄O₅
Molecular Weight: 310.30
Catalog: Natural product Xanthone
Create Date: 2016-11-11 00:27:35
Modify Date: 2024-01-14 18:01:18
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].

Name	5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one
Synonyms	5,10-dihydroxy-2,2-dimethylpyrano(3,2-b)xanthen-6(2H)-one 6-Dehydroxyjacareubin 6-Deoxyjacareubin 6-Desoxyjacareubin 5,10-Dihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one Jacareubin,6-deoxy 2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,10-dihydroxy-2,2-dimethyl-

Description	6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease
In Vitro	6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。
In Vivo	6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1]. Animal Model: Male SOD1G93A mice (eight weeks)[1] Dosage: 5 mg/kg Administration: Intraperitoneally (i.p.), every seven days for 1 month Result: Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.
References	[1]. Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51.

Hazard Codes	Xi