14882-18-9

14882-18-9 structure

Name: Bismuth Subsalicylate
Chemical Name: bismuth subsalicylate
CAS Number: 14882-18-9
Molecular Formula: C₇H₅BiO₄
Molecular Weight: 362.093
Catalog: API Synthetic anti-infective drugs Antihelium drug
Create Date: 2018-03-21 08:00:00
Modify Date: 2024-01-02 12:24:37
Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.Target: OthersBismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2 [1]. Bismuth Subsalicylate is the active ingredient in Pepto-Bismol, an anti-diarrhea medication and antacid. In the gastrointestinal tract, Bismuth Subsalicylate is converted to salicylic acid and insoluble bismuth salts [2]. Bismuth subsalicylate treatment for 8 weeks is safe and well tolerated. This regimen appears to be efficacious for the treatment of microscopic colitis and is worthy of further study in a controlled trial [3].

Name	bismuth subsalicylate
Synonyms	Bismuth(III) salicylate basic Bismuth oxide salicylate Bismuth Subsalicylate 4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy- EINECS 238-953-1 MFCD00085368 Bismuth(III) subsalicylate Bismuth, (2-hydroxybenzoato-O1,O2)oxo- 2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one Bismuth oxysalicylate Pepto-Bismol

Description	Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.Target: OthersBismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2 [1]. Bismuth Subsalicylate is the active ingredient in Pepto-Bismol, an anti-diarrhea medication and antacid. In the gastrointestinal tract, Bismuth Subsalicylate is converted to salicylic acid and insoluble bismuth salts [2]. Bismuth subsalicylate treatment for 8 weeks is safe and well tolerated. This regimen appears to be efficacious for the treatment of microscopic colitis and is worthy of further study in a controlled trial [3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> PGE synthase Research Areas >> Neurological Disease
References	[1]. Sox, T.E. and C.A. Olson, Binding and killing of bacteria by bismuth subsalicylate. Antimicrob Agents Chemother, 1989. 33(12): p. 2075-82. [2]. Bierer, D.W., Bismuth subsalicylate: history, chemistry, and safety. Rev Infect Dis, 1990. 12 Suppl 1: p. S3-8. [3]. Fine, K.D. and E.L. Lee, Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis. Gastroenterology, 1998. 114(1): p. 29-36.

Boiling Point	336.3ºC at 760mmHg
Melting Point	>35ºC
Molecular Formula	C₇H₅BiO₄
Molecular Weight	362.093
Flash Point	144.5ºC
Exact Mass	361.999176
PSA	55.76000
LogP	0.97400
Vapour Pressure	4.45E-05mmHg at 25°C
Water Solubility	Practically insoluble in water, alcoholSoluble in acid and alkali. Insoluble in cold water, ethanol, diethyl ether and n-octanol.

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: AJCPAI American Journal of Clinical Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1931- Volume(issue)/page/year: 14,392,1944

TOXIC EFFECTS :: Musculoskeletal - joints Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: ADSYAF Archives of Dermatology and Syphilology. (Chicago, IL) V.1-62, 1920-50. For publisher information, see ARDEAC. Volume(issue)/page/year: 41,1076,1940

REFERENCE :: AJSGA3 American Journal of Syphilis, Gonorrhea and Venereal Diseases. (St. Louis, MO) V.20-38, 1936-54. Discontinued. Volume(issue)/page/year: 26,84,1942 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80378 No. of Facilities: 96 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 3666 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80378 No. of Facilities: 405 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 4036 (estimated) No. of Female Employees: 2022 (estimated)

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	EB2985000