Bismuth Subsalicylate

Modify Date: 2025-08-30 16:39:45

Bismuth Subsalicylate Structure
Bismuth Subsalicylate structure
 Common Name Bismuth Subsalicylate
CAS Number 14882-18-9 Molecular Weight 362.093
Density N/A Boiling Point 336.3ºC at 760mmHg
Molecular Formula C7H5BiO4 Melting Point >35ºC
MSDS N/A Flash Point 144.5ºC

 Use of Bismuth Subsalicylate


Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.Target: OthersBismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2 [1]. Bismuth Subsalicylate is the active ingredient in Pepto-Bismol, an anti-diarrhea medication and antacid. In the gastrointestinal tract, Bismuth Subsalicylate is converted to salicylic acid and insoluble bismuth salts [2]. Bismuth subsalicylate treatment for 8 weeks is safe and well tolerated. This regimen appears to be efficacious for the treatment of microscopic colitis and is worthy of further study in a controlled trial [3].

 Names

Name bismuth subsalicylate
Synonym More Synonyms

 Bismuth Subsalicylate Biological Activity

Description Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.Target: OthersBismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2 [1]. Bismuth Subsalicylate is the active ingredient in Pepto-Bismol, an anti-diarrhea medication and antacid. In the gastrointestinal tract, Bismuth Subsalicylate is converted to salicylic acid and insoluble bismuth salts [2]. Bismuth subsalicylate treatment for 8 weeks is safe and well tolerated. This regimen appears to be efficacious for the treatment of microscopic colitis and is worthy of further study in a controlled trial [3].
Related Catalog
References

[1]. Sox, T.E. and C.A. Olson, Binding and killing of bacteria by bismuth subsalicylate. Antimicrob Agents Chemother, 1989. 33(12): p. 2075-82.

[2]. Bierer, D.W., Bismuth subsalicylate: history, chemistry, and safety. Rev Infect Dis, 1990. 12 Suppl 1: p. S3-8.

[3]. Fine, K.D. and E.L. Lee, Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis. Gastroenterology, 1998. 114(1): p. 29-36.

 Chemical & Physical Properties

Boiling Point 336.3ºC at 760mmHg
Melting Point >35ºC
Molecular Formula C7H5BiO4
Molecular Weight 362.093
Flash Point 144.5ºC
Exact Mass 361.999176
PSA 55.76000
LogP 0.97400
Vapour Pressure 4.45E-05mmHg at 25°C
Water Solubility Practically insoluble in water, alcoholSoluble in acid and alkali. Insoluble in cold water, ethanol, diethyl ether and n-octanol.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EB2985000
CHEMICAL NAME :
Bismuth, oxo(salicylato)-
CAS REGISTRY NUMBER :
14882-18-9
LAST UPDATED :
199504
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C7-H5-Bi-O4
MOLECULAR WEIGHT :
362.10
WISWESSER LINE NOTATION :
QR BVO-BI-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
60 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
AJCPAI American Journal of Clinical Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1931- Volume(issue)/page/year: 14,392,1944
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
14480 ug/kg/9D-I
TOXIC EFFECTS :
Musculoskeletal - joints Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
ADSYAF Archives of Dermatology and Syphilology. (Chicago, IL) V.1-62, 1920-50. For publisher information, see ARDEAC. Volume(issue)/page/year: 41,1076,1940
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
17 mg/kg/5W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
AJSGA3 American Journal of Syphilis, Gonorrhea and Venereal Diseases. (St. Louis, MO) V.20-38, 1936-54. Discontinued. Volume(issue)/page/year: 26,84,1942 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80378 No. of Facilities: 96 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 3666 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80378 No. of Facilities: 405 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 4036 (estimated) No. of Female Employees: 2022 (estimated)

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS EB2985000

 Synonyms

Bismuth(III) salicylate basic
Bismuth oxide salicylate
Bismuth Subsalicylate
4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy-
EINECS 238-953-1
MFCD00085368
Bismuth(III) subsalicylate
Bismuth, (2-hydroxybenzoato-O1,O2)oxo-
2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one
Bismuth oxysalicylate
Pepto-Bismol
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