69693-13-6

69693-13-6 structure

Name: Palvanil
Chemical Name: N-[(4-hydroxy-3-methoxyphenyl)methyl]hexadecanamide
CAS Number: 69693-13-6
Molecular Formula: C₂₄H₄₁NO₃
Molecular Weight: 391.58700
Catalog: Research Areas Infection
Create Date: 2017-09-03 12:13:53
Modify Date: 2024-01-10 17:38:55
Palvanil is a capsaicin analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects[1][2].

Name	N-[(4-hydroxy-3-methoxyphenyl)methyl]hexadecanamide
Synonyms	N-vanillyl-palmitamide N-Vanillyl-palmitinamid N-vanillyl-hexadecanamide Palvanil

Description	Palvanil is a capsaicin analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Palvanil (0.1-1000 nM; 0-300 min) leads to calcium increasment in intracellular[1]. Cell Viability Assay[1] Cell Line: HEK-293 cells Concentration: 0.1, 0.5, 1, 5, 10, 50, 100 and 1000 nM Incubation Time: 0-300 min Result: Produced a dose-dependent increase in intracellular calcium with a EC50 of 0.65 nM.
In Vivo	Palvanil (Subcutaneous injection; 1 or 10 mg/kg; once) treatment shows hypothermic effect[2]. Palvanil (Intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces capsaicin-induced bronchoconstriction[2]. Palvanil (Intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on formalin-induced nocifensive behavior[2]. Palvanil (Intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits carrageenan-induced inflammation[2]. Palvanil (Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia in SNI mice[2]. Animal Model: Male CD-1 mice[2] Dosage: 1 or 10 mg/kg Administration: Subcutaneous injection; 1 or 10 mg/kg; once Result: Led to a slight and short lasting hypothermic effect, produced late hyperthermia. Animal Model: Female BALB/C mice[2] Dosage: 100 μL (15 nM) per mouse Administration: Intraperitoneal injection; 100 μL (15 nM) per mouse; once Result: Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s). Animal Model: Male CD-1 mice received formalin[2] Dosage: 0.5, 0.75, and 1 mg/kg Administration: Intravenous injection; 0.5, 0.75, and 1 mg/kg; once Result: Reduced the second phase of formalin-induced nociceptive behaviour in a dose-dependent manner. Animal Model: Male C57BL/6J mice with acute inflammation induced by carrageenan[2] Dosage: 2.5 mg/kg Administration: Intravenous injection; 2.5 mg/kg; once Result: Reduced the volume of the oedema in the ipsilateral hind paw (64%). Animal Model: Male CD-1 mice[2] Dosage: 0.5 and 1 mg/kg Administration: Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days Result: Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner.
References	[1]. Luciano De Petrocellis, et al. N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Pharmacol Res. 2011 Apr;63(4):294-9. [2]. Livio Luongo, et al. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012 Sep;66(3):243-50.