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Dayang Chem (Hangzhou) Co., Ltd.
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naturewill
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Henan Tianfu Chemical Co., Ltd.
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Zhongshan Xingrui Chemical Co. , Ltd.
China
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38183-03-8

38183-03-8 structure

38183-03-8 structure

Name: 7,8-Dihydroxyflavone
Chemical Name: 7,8-dihydroxyflavone
CAS Number: 38183-03-8
Molecular Formula: C₁₅H₁₀O₄
Molecular Weight: 254.24
Catalog: Biochemical Plant extracts
Create Date: 2018-07-12 11:40:54
Modify Date: 2026-07-03 13:44:27
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].

Name	7,8-dihydroxyflavone
Synonyms	7,8-dihydroxy-2-phenyl-chromen-4-one 7,8-Dihydroxyflavone Hydrate EINECS 253-812-4 DIHYDROXYFLAVONE, 7,8 7,8-dihydroxy-2-phenyl-4-benzopyrone 7,8-DHF 7,8-dihydroxy-2-phenylchromen-4-one 7,8-DIHYDROXYFLAVONE 7,8-dihydroxy-2-phenyl-chromone TIMTEC-BB SBB000930 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl 7,8-Dihydroxyflavone hydrate 7,8-dihydroxyflavone (7,8-DHF) 2-(Dimethylamino)ethyl methacrylate 2-2 7,8-DIHYDROXYFLAVONE 7,8-DIHYDROXYFLAVONE TrkB Agonist, 7,8-Dihydroxyflavone 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one 8-Dihydroxyflavone 7,8-dihydroxy Flavones 7,8-DIHYDROXY 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one 2-Phenyl-7,8-dihydroxy-4H-1-benzopyran-4-one 7,8-Di-OH flavone Flavone,7,8-dihydroxy- (6CI) 7,8-Dihydroxy-2-phenyl-4H-chroMen-4-one 7,8-DihydroxyflavoneHydrate> 6,7-dihydroxy-2-phenyl-4H-chromen-4-one 7,8-dihydroxy Flavones, 7,8-DHF MFCD00006836 AcibenzolAcid Impurity 16 7,8-Dihydroxyflavone (7,8-DHF), TrkB rector agonist. Flavonoid DIHYDROXYFLAVONE, 7,8-(RG)

Description	7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Neurological Disease
Target	TrkB[1]
In Vitro	7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1].
In Vivo	7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].
References	[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50.

Density	1.4±0.1 g/cm3
Boiling Point	494.4±45.0 °C at 760 mmHg
Melting Point	243-246°C
Molecular Formula	C₁₅H₁₀O₄
Molecular Weight	254.24
Flash Point	193.5±22.2 °C
Exact Mass	254.057907
PSA	70.67000
LogP	2.51
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.699
Storage condition	Store at +4°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3004000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-

CAS REGISTRY NUMBER :: 38183-03-8

BEILSTEIN REFERENCE NO. :: 0234350

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H10-O4

MOLECULAR WEIGHT :: 254.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 12500 ug/L

REFERENCE :: PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 27,1017,1988

Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	S24/25
RTECS	DJ3004000
HS Code	2914400090

Precursor 6
110865-10-6 6665-86-7 528-21-2 98-88-4
93-97-0 2652-27-9
DownStream 1
65548-54-1

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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