7,8-Dihydroxyflavone

Modify Date: 2024-01-01 18:56:27

7,8-Dihydroxyflavone structure	Common Name	7,8-Dihydroxyflavone
	CAS Number	38183-03-8	Molecular Weight	254.24
	Density	1.4±0.1 g/cm3	Boiling Point	494.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₀O₄	Melting Point	243-246°C
	MSDS	Chinese USA	Flash Point	193.5±22.2 °C

Use of 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].

Name	7,8-dihydroxyflavone
Synonym	More Synonyms

Description	7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Neurological Disease
Target	TrkB[1]
In Vitro	7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1].
In Vivo	7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].
References	[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50.

Density	1.4±0.1 g/cm3
Boiling Point	494.4±45.0 °C at 760 mmHg
Melting Point	243-246°C
Molecular Formula	C₁₅H₁₀O₄
Molecular Weight	254.24
Flash Point	193.5±22.2 °C
Exact Mass	254.057907
PSA	70.67000
LogP	2.51
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.699
Storage condition	Store at +4°C

7,8-Dihydroxyflavone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3004000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-

CAS REGISTRY NUMBER :: 38183-03-8

BEILSTEIN REFERENCE NO. :: 0234350

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H10-O4

MOLECULAR WEIGHT :: 254.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 12500 ug/L

REFERENCE :: PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 27,1017,1988

Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	S24/25
RTECS	DJ3004000
HS Code	2914400090

Precursor 6
CAS#:110865-10-6 4-oxo-2-phenyl-... CAS#:6665-86-7 7-Hydroxyflavone CAS#:528-21-2 Gallacetophenone CAS#:98-88-4 Benzoyl chloride
CAS#:93-97-0 Benzoic anhydride CAS#:2652-27-9 1-[2-hydroxy-3,...
DownStream 1
CAS#:65548-54-1 7,8-dimethoxy-2...

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

7,8-dihydroxy-2-phenylchromen-4-one

7,8-Dihydroxyflavone Hydrate

7,8-Dihydroxy-2-phenyl-4H-chromen-4-one

EINECS 253-812-4

7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

MFCD00006836

7,8-Dihydroxyflavone

4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-

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China
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China
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China
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China
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China
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7,8-Dihydroxyflavone

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