7,8-Dihydroxyflavone

Modify Date: 2025-08-24 20:57:39

7,8-Dihydroxyflavone Structure
7,8-Dihydroxyflavone structure
 Common Name 7,8-Dihydroxyflavone
CAS Number 38183-03-8 Molecular Weight 254.24
Density 1.4±0.1 g/cm3 Boiling Point 494.4±45.0 °C at 760 mmHg
Molecular Formula C15H10O4 Melting Point 243-246°C
MSDS Chinese USA Flash Point 193.5±22.2 °C

 Use of 7,8-Dihydroxyflavone


7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].

 Names

Name 7,8-dihydroxyflavone
Synonym More Synonyms

 7,8-Dihydroxyflavone Biological Activity

Description 7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
Related Catalog
Target

TrkB[1]

In Vitro 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1].
In Vivo 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].
References

[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 494.4±45.0 °C at 760 mmHg
Melting Point 243-246°C
Molecular Formula C15H10O4
Molecular Weight 254.24
Flash Point 193.5±22.2 °C
Exact Mass 254.057907
PSA 70.67000
LogP 2.51
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.699
Storage condition Store at +4°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ3004000
CHEMICAL NAME :
4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-
CAS REGISTRY NUMBER :
38183-03-8
BEILSTEIN REFERENCE NO. :
0234350
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H10-O4
MOLECULAR WEIGHT :
254.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
12500 ug/L
REFERENCE :
PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 27,1017,1988

 Safety Information

Hazard Codes Xn
Risk Phrases 22
Safety Phrases S24/25
RTECS DJ3004000
HS Code 2914400090

 Synthetic Route

 Customs

HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

7,8-dihydroxy-2-phenylchromen-4-one
7,8-Dihydroxyflavone Hydrate
7,8-Dihydroxy-2-phenyl-4H-chromen-4-one
EINECS 253-812-4
7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
MFCD00006836
7,8-Dihydroxyflavone
4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

7,8-Dihydroxyflavone suppliers

Price: ￥507/1g

Reference only. check more 7,8-Dihydroxyflavone price

Related Compounds: More...
7,8-Dihydroxyflavone
607373-46-6
7,8-dihydroxyflavone
59887-99-9
3',4'-dimethoxy-7,8-dihydroxyflavone
110865-15-1
4'-Dimethylamino 7,8-Dihydroxyflavone
1205548-00-0
4'-Dimethylamino 7,8-Dihydroxyflavone Dimethyl Ether
1205548-03-3
7,8-dihydroxyflavanone
51876-18-7
7,8,11,11a-Tetrahydro-3,6,10-trimethylcyclodeca[b]furan-2(4H)-one
38146-68-8
7,8-dimethoxy-4-(3,4,5-trimethoxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole,hydrochloride
35202-52-9
7,8-dimethylfluoranthene
38048-87-2
N,N-Diethyl-2-methoxynicotinamide
125335-73-1
2,6-bis((E)-5-(3-nitrobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanoic acid
13112-36-2
(E)-N-(5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-4-nitrobenzamide
299950-56-4
(E)-N-(5-(4-(dimethylamino)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-4-nitrobenzamide
303026-51-9
(E)-N-(2-chlorophenyl)-2-(5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetamide
389077-24-1
(Z)-3-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)propanamide
392325-22-3
2-((E)-4-oxo-5-((Z)-3-phenylallylidene)-2-thioxothiazolidin-3-yl)-2-phenylacetic acid
301682-74-6
(E)-5-(4-methoxybenzylidene)-2-(4-(3-((E)-5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoyl)piperazin-1-yl)thiazol-4(5H)-one
305375-17-1
(E)-5-(3-bromobenzylidene)-3-(3-morpholino-3-oxopropyl)-2-thioxothiazolidin-4-one
461680-05-7
(Z)-3-(5-(3-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(4-methylthiazol-2-yl)propanamide
476634-59-0
Chemsrc provides 7,8-Dihydroxyflavone(CAS#:38183-03-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 7,8-Dihydroxyflavone are included as well.>> amp version: 7,8-Dihydroxyflavone

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved