Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-METHYL-4-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLIN-8-AMINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang
Email: enquiry@dycnchem.com

24526-64-5

24526-64-5 structure

Name: Nomifensine
Chemical Name: nomifensine
CAS Number: 24526-64-5
Molecular Formula: C₁₆H₁₈N₂
Molecular Weight: 238.327
Catalog: API Nervous system medication Antidepressant, manic
Create Date: 2018-04-24 08:00:00
Modify Date: 2026-07-12 18:47:49
Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

Name	nomifensine
Synonyms	Nomifensine, 10 mM in DMSO Merital R/S-nomifensine 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine (±)-Nomifensine 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl Nomifensin D,L-nomifensine 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin NOMIFENSINE MALEATE //BP 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline Dopamine Rector,Inhibitor,Nomifensine,inhibit Psicronizer 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine Nomifenison Nomiphensine Nomifensine Maleate linamiphen alival 8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl 8-amino-4-phenyl-2-methyl-1,2,3,4-tetrahydro-isoquinoline Hostalival UNII:1LGS5JRP31 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

Description	Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease

Density	1.1±0.1 g/cm3
Boiling Point	378.4±42.0 °C at 760 mmHg
Melting Point	179-181°
Molecular Formula	C₁₆H₁₈N₂
Molecular Weight	238.327
Flash Point	164.0±23.0 °C
Exact Mass	238.147003
PSA	29.26000
LogP	2.15
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.623
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX4912700

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-

CAS REGISTRY NUMBER :: 24526-64-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H18-N2

MOLECULAR WEIGHT :: 238.36

WISWESSER LINE NOTATION :: T66 CNT&J C1 ER& JZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7 mg/kg/7D-I

TOXIC EFFECTS :: Blood - hemorrhage Blood - thrombocytopenia

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,830,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,247,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - aggression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,873,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 128 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 17,37,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 264 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 18,1,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 mg/kg

SEX/DURATION :: lactating female 1 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 23,103,1987

Hazard Codes	Xn: Harmful;
Risk Phrases	22-36/37/38
Safety Phrases	26-36
RIDADR	UN 3249
WGK Germany	3
RTECS	NX4912800
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933499090

Precursor 10
65514-97-8 56222-08-3 102436-67-9 70-11-1
85660-33-9 1904-69-4 552-89-6 119810-30-9
532-27-4 529-23-7
DownStream 5
89664-20-0 89664-18-6 91454-32-9 99633-74-6
63806-80-4

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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