24526-64-5

• 常用中文名：诺米芬辛
• 常用英文名：Nomifensine
• CAS号：24526-64-5
• 分子式：C₁₆H₁₈N₂
• 分子量：238.327
• 相关类别： 原料药 神经系统用药 抗抑郁、躁狂药
• 发布时间：2018-04-24 08:00:00
• 更新时间：2025-08-26 19:22:45
• Nomifensine是去甲肾上腺素 - 多巴胺再摄取抑制剂, 通过阻断多巴胺和去甲肾上腺素再摄取转运体, 来增加突触提供给受体去甲肾上腺素和多巴胺的量。

名称

• 中文名: 诺米芬辛
• 英文名: nomifensine
• 中文别名: 苯异喹胺; 2-甲基-4-苯基-8-氨基-1,2,3,4-四氢异喹啉
• 英文别名: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine; 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin; Merital; Nomifensine; R/S-nomifensine; Nomiphensine; Nomifenison; Nomifensine Maleate; (±)-Nomifensine; alival; Nomifensin; linamiphen; 8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl; D,L-nomifensine; 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin; 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-; 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline; 8-amino-4-phenyl-2-methyl-1,2,3,4-tetrahydro-isoquinoline; 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline; Psicronizer; 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine; Hostalival; UNII:1LGS5JRP31; 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 378.4±42.0 °C at 760 mmHg
• 熔点: 179-181°
• 分子式: C₁₆H₁₈N₂
• 分子量: 238.327
• 闪点: 164.0±23.0 °C
• 精确质量: 238.147003
• PSA: 29.26000
• LogP: 2.15
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.623
• 储存条件: 2-8℃

生物活性

• 描述: Nomifensine是去甲肾上腺素-多巴胺再摄取抑制剂, 通过阻断多巴胺和去甲肾上腺素再摄取转运体, 来增加突触提供给受体去甲肾上腺素和多巴胺的量。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NX4912700 CHEMICAL NAME : Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl- CAS REGISTRY NUMBER : 24526-64-5 LAST UPDATED : 199512 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C16-H18-N2 MOLECULAR WEIGHT : 238.36 WISWESSER LINE NOTATION : T66 CNT&J C1 ER& JZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 7 mg/kg/7D-I TOXIC EFFECTS : Blood - hemorrhage Blood - thrombocytopenia REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,830,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,247,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 260 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - aggression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,873,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 128 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 17,37,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 264 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 18,1,1979 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 4 mg/kg SEX/DURATION : lactating female 1 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 23,103,1987

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 22-36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: UN 3249
• WGK德国: 3
• RTECS号: NX4912800
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2933499090

合成路线

上下游产品

上游产品  10
65514-97-8 56222-08-3 102436-67-9 70-11-1
85660-33-9 1904-69-4 552-89-6 119810-30-9
532-27-4 529-23-7
下游产品  5
89664-20-0 89664-18-6 91454-32-9 99633-74-6
63806-80-4

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%