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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：诺米芬新
纯度：99.0%
规格：
联系人：徐经理
联系电话：13311869306

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Nomifensine
纯度：98.0%
规格：100mg/50mg/25mg/1g
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：诺米芬辛
纯度：97.0%
规格：500mg/1g/1g/1g
联系人：阿拉丁
联系电话：400-620-6333

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]Nomifensine,≥99%
纯度：99.0%
规格：50mg/100mg
联系人：夏言
联系电话：18016376636

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24526-64-5生产厂家

24526-64-5价格

24526-64-5

24526-64-5结构式

常用中文名：诺米芬辛
常用英文名：Nomifensine
CAS号：24526-64-5
分子式：C₁₆H₁₈N₂
分子量：238.327
相关类别：原料药神经系统用药抗抑郁、躁狂药
发布时间：2018-04-24 08:00:00
更新时间：2024-01-08 18:49:54
Nomifensine是去甲肾上腺素-多巴胺再摄取抑制剂, 通过阻断多巴胺和去甲肾上腺素再摄取转运体, 来增加突触提供给受体去甲肾上腺素和多巴胺的量。

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中文名	诺米芬辛
英文名	nomifensine
中文别名	苯异喹胺 2-甲基-4-苯基-8-氨基-1,2,3,4-四氢异喹啉
英文别名	1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamin Merital Nomifensine R/S-nomifensine Nomiphensine Nomifenison Nomifensine Maleate (±)-Nomifensine alival Nomifensin linamiphen 8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl D,L-nomifensine 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-isoquinolin 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl- 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline 8-amino-4-phenyl-2-methyl-1,2,3,4-tetrahydro-isoquinoline 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline Psicronizer 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine Hostalival UNII:1LGS5JRP31 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine

描述	Nomifensine是去甲肾上腺素-多巴胺再摄取抑制剂, 通过阻断多巴胺和去甲肾上腺素再摄取转运体, 来增加突触提供给受体去甲肾上腺素和多巴胺的量。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体信号通路 >> 神经信号通路 >> 多巴胺受体研究领域 >> 神经疾病

密度	1.1±0.1 g/cm3
沸点	378.4±42.0 °C at 760 mmHg
熔点	179-181°
分子式	C₁₆H₁₈N₂
分子量	238.327
闪点	164.0±23.0 °C
精确质量	238.147003
PSA	29.26000
LogP	2.15
蒸汽压	0.0±0.9 mmHg at 25°C
折射率	1.623
储存条件	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX4912700

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-8-amino-2-methyl-4-phenyl-

CAS REGISTRY NUMBER :: 24526-64-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H18-N2

MOLECULAR WEIGHT :: 238.36

WISWESSER LINE NOTATION :: T66 CNT&J C1 ER& JZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7 mg/kg/7D-I

TOXIC EFFECTS :: Blood - hemorrhage Blood - thrombocytopenia

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,830,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,247,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - aggression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,873,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 128 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 17,37,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 264 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 18,1,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 mg/kg

SEX/DURATION :: lactating female 1 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 23,103,1987

危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	22-36/37/38
安全声明 (欧洲)	26-36
危险品运输编码	UN 3249
WGK德国	3
RTECS号	NX4912800
包装等级	III
危险类别	6.1(b)
海关编码	2933499090

上游产品 10
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海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%