67227-57-0

67227-57-0 structure

Name: Fenoldopam (mesylate)
Chemical Name: 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,methanesulfonic acid
CAS Number: 67227-57-0
Molecular Formula: C₁₇H₂₀ClNO₆S
Molecular Weight: 401.86
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-08-08 23:46:57
Modify Date: 2024-01-02 10:59:51
Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2].

Name	9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,methanesulfonic acid
Synonyms	EINECS 266-612-7 Fenoldopam monomethanesulfonate MFCD04112986 6-Chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1H-3-benzazepinium methanesulphonate Corlopam Fenoldopam methanesulfonate 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Fenoldopam mesylate 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine methanesulfonate 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate CORLOPAM MESYLATE Fenoldopam (mesylate)

Description	Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Cardiovascular Disease
References	[1]. Grenader, A. and D.P. Healy, Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther, 1991. 258(1): p. 193-8. [2]. Nichols, A.J., R.R. Ruffolo, Jr., and D.P. Brooks, The pharmacology of fenoldopam. Am J Hypertens, 1990. 3(6 Pt 2): p. 116S-119S.

Density	1.38g/cm3
Boiling Point	522.6ºC at 760 mmHg
Molecular Formula	C₁₇H₂₀ClNO₆S
Molecular Weight	401.86
Flash Point	269.9ºC
PSA	104.24000
LogP	3.77680
Storage condition	room temp

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H317-H319
Precautionary Statements	P280-P301 + P312 + P330-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	22-36-42/43
Safety Phrases	22-26-36/37/39
RIDADR	NONH for all modes of transport

75-75-2

67227-56-9

67227-57-0

Literature: US2006/194967 A1, ; Page/Page column 7-8 ;

Precursor 2
75-75-2 67227-56-9
DownStream 0

67227-57-0	1246815-23-5
67227-56-9	67287-54-1
181217-39-0	2763365-40-6
833482-77-2	202464-88-8
157605-25-9	144143-96-4