1189929-21-2

1189929-21-2 structure
1189929-21-2 structure
  • Name: 5-O-Desmethyl donepezil-d5
  • Chemical Name: 5-hydroxy-6-methoxy-2-[[1-[(2,3,4,5,6-pentadeuteriophenyl)methyl]piperidin-4-yl]methyl]-2,3-dihydroinden-1-one
  • CAS Number: 1189929-21-2
  • Molecular Formula: C23H22D5NO3
  • Molecular Weight: 370.50
  • Create Date: 2016-04-30 16:14:09
  • Modify Date: 2024-01-22 11:00:36
  • 5-O-Desmethyl donepezil-d5 is deuterium labeled 5-O-Desmethyl donepezil.

Name 5-hydroxy-6-methoxy-2-[[1-[(2,3,4,5,6-pentadeuteriophenyl)methyl]piperidin-4-yl]methyl]-2,3-dihydroinden-1-one
Synonyms 5-O-Desmethyl Donepezil-d5
Description 5-O-Desmethyl donepezil-d5 is deuterium labeled 5-O-Desmethyl donepezil.
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Molecular Formula C23H22D5NO3
Molecular Weight 370.50
Exact Mass 370.23000
PSA 49.77000
LogP 3.99600