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  • DC Chemicals Limited
  • China
  • Product Name: Cynarin
  • Price: $600.0/50mg $1000.0/100mg $1900.0/250mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
Related CAS#:
30964-13-7 19870-46-3
1884-24-8 212891-05-9
1884-23-7 117047-07-1
117-14-6 167940-09-2
207569-02-6 846-26-4

30964-13-7

30964-13-7 structure
30964-13-7 structure
  • Name: 1,5-Dicaffeoylquinic acid
  • Chemical Name: 1,3-dicaffeoylquinic acid
  • CAS Number: 30964-13-7
  • Molecular Formula: C25H24O12
  • Molecular Weight: 516.451
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-09-20 15:22:46
  • Modify Date: 2024-01-02 19:46:55
  • Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.
Name 1,3-dicaffeoylquinic acid
Synonyms Listrocol
Acido,1,4-dicaffeilchinico
(1R,3R,4S,5R)-1,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}-4,5-dihydroxycyclohexanecarboxylic acid
[1R-(1a,3a,4a,5b)]-1,3-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-4,5-dihydroxycyclohexanecarboxylic Acid
1,5-Dicaffeoylquinic acid
1,3-DICAFFEOYLQUINIC ACID
1,3-O-Dicaffeoylquinic acid
(1R,3R,4S,5R)-1,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-4,5-dihydroxycyclohexanecarboxylic acid
1-Carboxy-4,5-dihydroxy-1,3-cyclohexylenebis-(3,4-dihydroxycinnamate)
3,4-Dihydroxycinnamic Acid 1-Carboxy-4,5-dihydroxy-1,3-cyclohexylene Ester
CINARINE
1,4-Dicaffeylquinic acid
MFCD00075714
Caffeic Acid 1-Carboxy-4,5-dihydroxy-1,3-cyclohexylene Ester
Cinarcaf
Cyclohexanecarboxylic acid, 1,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-
1,5-Dicaffeylquinic Acid
Cynarine
Cynara scolymus L,
Quinic Acid 1,5-Dicaffeic Ester
Plemocil
Cynarin
CINARAN
EINECS 214-655-7
Dicaffeoylquinic Acid, 1,3-
Description Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.
Related Catalog
In Vitro Cynarin inhibits taste receptors, making water to be sweet. It has been shown to have some pharmacological properties including hypocholesterolemic, hepatoprotective, antiviral, antibacterial, and antihistamic effects. Cynarin has marked antioxidant, anticholinergic, reducing ability, radical-scavenging, and metal-binding activities. Cynarin demonstrates 87.72% inhibition of linoleic acid lipid peroxidation at 30 mg/mL concentration. Cynarin exhibits effective DMPD+, ABTS+/sup>, O2-, DPPH1, and H2O2 scavenging effects, reducing capabilities and Fe2+ chelating effects. IC50 and Ki of cynarin for acetylcholinesterase enzyme inhibition are 243.67nM and 39.34±13.88 nM, respectively[1]. Cynarin is a potential immunosuppressant that blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin blocks about 87% of the CD28-dependent "signal 2" pathway of T-cell activation under the condition of one to one ratio of T-cell and B-cell. Cynarin binds to the "G-pocket" of CD28 and thus interrupts the site of interaction between CD28 and CD80[2].
Cell Assay The cytotoxicity of cynarin treatment of T-cells is measured by MTT colorimetric assay. 100 μL Jurkat cells are incubated with cynarin (0-1000 μg/mL) for 24 h at 37°C. The cell solution is then centrifuged and the supernatant removed. 200 μL of MTT is added and the cell solution is incubated again for 4 h at 37°C. 200 μL of DMSO lysis buffer is added into the cell medium and the concentration of dissolved MTT crystals is measured by plate reader at 560 nm[2].
References

[1]. Topal M, et al. Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.). J Enzyme Inhib Med Chem. 2016;31(2):266-75.

[2]. Dong GC, et al. Blocking effect of an immuno-suppressive agent, cynarin, on CD28 of T-cell receptor. Pharm Res. 2009 Feb;26(2):375-81.

Density 1.6±0.1 g/cm3
Boiling Point 819.9±65.0 °C at 760 mmHg
Melting Point 225-227 °C
Molecular Formula C25H24O12
Molecular Weight 516.451
Flash Point 278.1±27.8 °C
Exact Mass 516.126770
PSA 211.28000
LogP 1.64
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.719
Storage condition 2-8°C
RIDADR NONH for all modes of transport
HS Code 2932999099
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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