120014-06-4
120014-06-4 structure
- Name: donepezil
- Chemical Name: donepezil
- CAS Number: 120014-06-4
- Molecular Formula: C24H29NO3
- Molecular Weight: 379.492
- Catalog: API Nervous system medication Brain metabolism regulating drug
- Create Date: 2018-07-05 11:50:31
- Modify Date: 2026-07-23 12:20:31
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Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.Target: AChEDonepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively [1]. Donepezil inhibits the carbachol-stimulated increase in intracellular Ca2+ concentration in human SHSY5Y neuroblastoma cells in a concentration dependent manner, indicating that Donepezil have muscarinic antagonist activity. Intraperitoneal administration of Donepezil in rats produces a dose dependent increase in salivation and tremor, which are overt cholinergic behavioural signs, with an ED50 of 6 μmol/kg. Donepezil is found to be somewhat less potent with a ED50 of 50 μmol/kg following oral administration [2]. A recent study shows that Donepezil can protect human umbilical vein endothelial cells (HUVECs) against H2O2-induced cell injury. This may be useful as a potential therapy for oxidative stress in cardiovascular and cerebrovascular diseases [3].
| Name | donepezil |
|---|---|
| Synonyms |
Donezil hydrochloride Monohydra
2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one 5,6-Dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydro-1H-inden-1-one 2-[((1-benzyl-4-piperidyl) methyl] -5, 6-dimethoxy-2, 3-dihydroindene - 1-one 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, hydrate(1:1:1) N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine (±)-E-2020 (2S)-2-[(1-benzylpiperidin-4-yl)Methyl]-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one HSDB7743 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one 5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one Donezil(2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one) n-1-one Donezil (under development) Donezil, >= 2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-one 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindanon-2-yl)methyl]piperidine Donezilo MFCD00912833 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde Donezil //BP Donezil (as hydrochloride) 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-on Donezil hydrochloride monohydrate 2-(1-Benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one DonezilQ: What is Donezil Q: What is the CAS Number of Donezil Q: What is the storage condition of Donezil Q: What e the applications of Donezil Donepezil hydrochloride monohydrate 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one onezil 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone Asciminib Impurity 15 DONEZIL 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE Donezepil 2-[(1-Benzyl-4-piper 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Donenil Donezil HCl (Base) 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one Donezine Aricept Donezil InterMediate Donezil, 10 mM in DMSO ict(Donezil) (2R)-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydroinden-1-one 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl] 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one Donepezil Base HSDB-7743 |
| Description | Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.Target: AChEDonepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively [1]. Donepezil inhibits the carbachol-stimulated increase in intracellular Ca2+ concentration in human SHSY5Y neuroblastoma cells in a concentration dependent manner, indicating that Donepezil have muscarinic antagonist activity. Intraperitoneal administration of Donepezil in rats produces a dose dependent increase in salivation and tremor, which are overt cholinergic behavioural signs, with an ED50 of 6 μmol/kg. Donepezil is found to be somewhat less potent with a ED50 of 50 μmol/kg following oral administration [2]. A recent study shows that Donepezil can protect human umbilical vein endothelial cells (HUVECs) against H2O2-induced cell injury. This may be useful as a potential therapy for oxidative stress in cardiovascular and cerebrovascular diseases [3]. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 527.9±50.0 °C at 760 mmHg |
| Melting Point | 207ºC |
| Molecular Formula | C24H29NO3 |
| Molecular Weight | 379.492 |
| Flash Point | 273.1±30.1 °C |
| Exact Mass | 379.214752 |
| PSA | 38.77000 |
| LogP | 4.71 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.578 |
| Water Solubility | 2.931 mg/L |
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | UN 2811 |
| Precursor 10 | |
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| DownStream 4 | |
![2-[(1-Benzylpiperidin-4-yl)hydroxyMethyl]-5,6-dimethoxyindan-1-one structure](https://image.chemsrc.com/caspic/159/197010-20-1.png)
![1-[(1-benzoylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one structure](https://image.chemsrc.com/caspic/487/120013-38-9.png)
![5-[(1-benzyl-4-piperidyl)methyl]-5-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione structure](https://image.chemsrc.com/caspic/324/848610-96-8.png)
