120012-04-6

120012-04-6 structure

Name: Dihydro Donepezil
Chemical Name: 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol
CAS Number: 120012-04-6
Molecular Formula: C₂₄H₃₁NO₃
Molecular Weight: 381.50800
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2018-12-27 21:21:07
Modify Date: 2026-07-01 18:39:17
Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively[1].

Name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol
Synonyms	2,3-Dihydro-5,6-diMethoxy-2-[[1-(phenylMethyl)-4-piperidinyl]Methyl]-1H-inden-1-ol Donezil-007 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol IND032 1H-Inden-1-ol, 2,3-dihydro-5,6- diMethoxy-2-[[1-(phenylMethyl)-4-piperidinyl]Methyl] Dihydro Donezil (Mixture of Diastereomers) 3-dihydro-1H-inden-1-ol Donezil IMpurity-VI Donezil impurity 13/Dihydro Donezil Impurity/2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-ol Donepezil Impurity 5 Donezil Dihydro IMpurity Dihydro Donezil Donezil Impurity 18 (Mixture of Diastereomers)

Description	Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.

120014-06-4

~68%

120012-04-6

Literature: Sugimoto; Iimura; Yamanishi; Yamatsu Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4821 - 4829

Precursor 1
120014-06-4
DownStream 0