57576-52-0

57576-52-0 structure

Name: thromboxane A2
Chemical Name: thromboxane A2
CAS Number: 57576-52-0
Molecular Formula: C₂₀H₃₂O₅
Molecular Weight: 352.46500
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2017-08-24 22:22:46
Modify Date: 2024-01-02 12:19:24
Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses[1][2].

Name	thromboxane A2

Description	Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite TP
References	[1]. Matthew A Sparks, et al. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension. 2013 Jan;61(1):166-73. [2]. Federica Moalli, et al. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med. 2014 Dec 15;211(13):2507-17.