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Related CAS#:
101-20-2 1322-40-3
1219799-29-7

101-20-2

101-20-2 structure
101-20-2 structure
Name triclocarban
Synonyms 3,4,4'-Trichlorocarbanilide
N-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)carbamimidic acid
3,4,4′-Trichlorocarbanilide
Methanol, 1-[(4-chlorophenyl)amino]-1-[(3,4-dichlorophenyl)imino]-, (Z)-
3,4,4'-trichlorodiphenylurea
Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-
cusiter
MFCD00013254
Triclocarban
Nobacter
genoface
GR DMVMR CG DG
Procutene
Carbanilide, 3,4,4'-trichloro-
TCC
CUTISAN
N-(4-Chlorophenyl)-N-(3,4-dichlorophenyl)-Urea
EINECS 202-924-1
1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea
3,4,4-Trichlorocarbanilide
N-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)urea
Description Triclocarban is an antimicrobial agent used in personal cleaning products.
Related Catalog
Target

Bacterial[1]
In Vitro Triclocarban at 300 nM potentiates the cytotoxicity of 300 µM H2O2 in rat thymocytes. 300 nM triclocarban itself does not increase the population of death cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells[1]. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells[2].
In Vivo Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM[1]. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring[3].
Animal Admin Rats: Sprague Dawley rats are provided control, 0.2% weight/weight (w/w), or 0.5% w/w triclocarban -supplemented chow through a series of 3 experiments that limited exposure to critical growth periods: gestation, gestation and lactation, or lactation only (cross-fostering) to determine the susceptible windows of exposure for developmental consequences[3].
References

[1]. Kanbara Y, et al. Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress. J Toxicol Sci. 2013 Feb;38(1):49-55.

[2]. Huang H, et al. The in vitro estrogenic activities of triclosan and triclocarban. J Appl Toxicol. 2014 Sep;34(9):1060-7.

[3]. Kennedy RC, et al. Early life triclocarban exposure during lactation affects neonate rat survival. Reprod Sci. 2015 Jan;22(1):75-89.

Density 1.4±0.1 g/cm3
Boiling Point 475.3±55.0 °C at 760 mmHg
Melting Point 254-256 °C(lit.)
Molecular Formula C13H9Cl3N2O
Molecular Weight 315.582
Flash Point 241.2±31.5 °C
Exact Mass 313.978058
PSA 41.13000
LogP 5.66
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.630
Storage condition Refrigerator
Stability Stable. Combustible. Incompatible with strong oxidizing agents strong bases.
Water Solubility <0.1 g/100 mL at 26 ºC
Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
Hazard Codes N
Risk Phrases R50/53
Safety Phrases S60-S61
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS FE1250000
Hazard Class 9.0
HS Code 2924299090
106-47-8 structure

106-47-8
102-36-3 structure

102-36-3

~%

101-20-2 structure

101-20-2
Literature: Journal of the American Chemical Society, , vol. 79, p. 1236,1242 Journal of Organic Chemistry, , vol. 24, p. 1676
104-12-1 structure

104-12-1
95-76-1 structure

95-76-1

~%

101-20-2 structure

101-20-2
Literature: US2818390 , ; US2846398 , ;
21368-28-5 structure

21368-28-5
95-76-1 structure

95-76-1

~%

101-20-2 structure

101-20-2
Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 37, # 10 p. 1066 - 1068
HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Chemsrc provides CAS#:101-20-2 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 101-20-2 | Chemsrc address: https://m.chemsrc.com/en/baike/329736.html

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