2498-50-2

2498-50-2 structure

Name: 4-Aminobenzamidine dihydrochloride
Chemical Name: 4-aminobenzenecarboximidamide,dihydrochloride
CAS Number: 2498-50-2
Molecular Formula: C₇H₁₁Cl₂N₃
Molecular Weight: 208.088
Catalog: Organic raw materials Amino compound Oxy-containing amino compound
Create Date: 2018-06-17 20:23:41
Modify Date: 2024-01-02 17:39:30
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice[1][2].

Name	4-aminobenzenecarboximidamide,dihydrochloride
Synonyms	4-AMBA dihydrochloride Benzenecarboximidamide, 4-amino-, hydrochloride (1:2) 4-aminobenzimidamide dihydrochloride 4-aminobenzimidine dihydrochloride MFCD00013001 4-aminobenzoamidine dihydrochloride P-AMINOBENZAMIDINE DIHCL 4-AMINOBENZAMIDINE 2HCL Benzenecarboximidamide,4-amino-,dihydrochloride 4-Aminobenzenecarboximidamide dihydrochloride p-Aminobenzamidine dihydrochloride Benzamidine,p-amino-,dihydrochloride EINECS 219-692-2 4-Aminobenzamidine Dihydrochloride

Description	4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (Ki=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer
Target	Trypsin[1] Ki: 82 μM (uPA)[1]
References	[1]. Nguyen AL, et al. The development and application of a new affinity partitioning system for enzyme isolation and purification. Enzyme Microb Technol. 1990 Sep;12(9):663-8. [2]. Billström A, et al. The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice. Int J Cancer. 1995 May 16;61(4):542-7.

TOXIC EFFECTS :: Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CV6126500

873-74-5

2498-50-2

Literature: US2014/114089 A1, ;