Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phentolamine mesilate
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Purity: 98.0%
Stocking Period: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Phentolamine mesilate
Price: ￥3218.0/5g ￥858.0/500mg ￥378.0/100mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Phentolamine mesilate
Price: $300.0/1g
Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Phentolamine mesilate
Price: ￥Inquiry/1g
Purity: 98.9%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phentolamine mesilate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

65-28-1

65-28-1 structure

Name: Phentolamine mesilate
Chemical Name: Phentolamine Mesylate
CAS Number: 65-28-1
Molecular Formula: C₁₈H₂₃N₃O₄S
Molecular Weight: 377.458
Catalog: API Circulatory system medication Peripheral vasodilator
Create Date: 2018-04-25 08:00:00
Modify Date: 2024-01-02 20:29:31
Phentolamine mesylate is a competitive, reversible α-adrenoceptor antagonist with an IC50 between 5 and 30 nM.

Name	Phentolamine Mesylate
Synonyms	EINECS 200-604-6 Phenol, 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, methanesulfonate (1:1) (salt) Phentolamine methanesulfonate salt 2-(m-Hydroxy-N-p-tolylanilinomethyl)-2-imidazoline Monomethanesulfonate (Salt) 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (salt) Phentolamine methanesulfonate Phentolamine methanesulphonate Phentolamine mesylate 2-(N'-p-Tolyl-N'-m-hydroxyphenylaminomethyl)-2-imidazoline Monomethanesulfonate (Salt) Methansulfonsäure--3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]benzolol(1:1) 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Monomethanesulfonate (Salt) Phentolamine mesilate Regitine 3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol methanesulfonate (1:1) 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol Monomethanesulfonate (Salt) Rogitine MFCD00134201 Phentolamine (mesylate)

Description	Phentolamine mesylate is a competitive, reversible α-adrenoceptor antagonist with an IC50 between 5 and 30 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease
References	[1]. Giussani, D.A., et al., Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero. J Physiol, 1995. 486 ( Pt 1): p. 249-55. [2]. Saeed, M., et al., Alpha-adrenoceptor blockade by phentolamine causes beta-adrenergic vasodilation by increased catecholamine release due to presynaptic alpha-blockade. J Cardiovasc Pharmacol, 1982. 4(1): p. 44-52.

Boiling Point	551ºC at 760 mmHg
Melting Point	180-182 °C(lit.)
Molecular Formula	C₁₈H₂₃N₃O₄S
Molecular Weight	377.458
Flash Point	287ºC
Exact Mass	377.140930
PSA	110.61000
LogP	3.18960
Storage condition	Refrigerator
Stability	Aq. Solutions Cannot be Stored
Water Solubility	50 MG/ML

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL5430000

CHEMICAL NAME :: Phenol, m-(N-(2-imidazolin-2-ylmethyl)-p-toluidino)-, monomethanesulfonate (salt)

CAS REGISTRY NUMBER :: 65-28-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H19-N3-O.C-H4-O3-S

MOLECULAR WEIGHT :: 377.50

WISWESSER LINE NOTATION :: T5M CN BUTJ B1NR CQ&R D1 &WSQ1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,667,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,667,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 5,101,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,667,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,667,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 4 mg/kg

SEX/DURATION :: female 22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 76,415,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6084 No. of Facilities: 26 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1307 (estimated) No. of Female Employees: 664 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	26-36
RIDADR	3249
WGK Germany	3
RTECS	SL5430000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933290090

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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