- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Atipamezole hydrochloride
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Atipamezole hydrochloride
- Price: ￥406.0/10mg ￥1216.0/50mg ￥816.0/25mg ￥1826.0/100mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Atipamezole HCl
- Price: $300.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Atipamezole HCl
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Atipamezole hydrochloride
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
104075-48-1
104075-48-1 structure
- Name: Atipamezole hydrochloride
- Chemical Name: Atipamezole hydrochloride
- CAS Number: 104075-48-1
- Molecular Formula: C14H17ClN2
- Molecular Weight: 248.751
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2018-08-15 21:33:04
- Modify Date: 2024-01-02 11:01:06
-
Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
| Name | Atipamezole hydrochloride |
|---|---|
| Synonyms |
5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, hydrochloride (1:1) Atipamezole hydrochloride 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride (1:1) 1H-Imidazole,4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-,monohydrochloride 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride 4-(2-Ethyl-2-indanyl)imidazole hydrochloride Atipamezole HCL 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazolehydrochloride Atipamezole (hydrochloride) |
| Description | Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM. |
|---|---|
| Related Catalog | |
| Target |
Ki: 1.6 nM[1] |
| In Vitro | The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. |
| In Vivo | Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1]. |
| References |
| Density | 1.115g/cm3 |
|---|---|
| Boiling Point | 367.1ºC at 760mmHg |
| Molecular Formula | C14H17ClN2 |
| Molecular Weight | 248.751 |
| Flash Point | 178ºC |
| Exact Mass | 248.108032 |
| PSA | 28.68000 |
| LogP | 3.65830 |
| Vapour Pressure | 1.17E-06mmHg at 25°C |
| Storage condition | Desiccate at RT |
| HS Code | 2933290090 |
|---|
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |