Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Brodimoprim
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

56518-41-3

56518-41-3 structure

Name: Brodimoprim
Chemical Name: Brodimoprim
CAS Number: 56518-41-3
Molecular Formula: C₁₃H₁₅BrN₄O₂
Molecular Weight: 339.19
Catalog: API Synthetic anti-infective drugs Antifungal drugs
Create Date: 2018-05-31 08:00:00
Modify Date: 2026-07-16 18:09:15
Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria[1].

Name	Brodimoprim
Synonyms	inhibit,oral,Inhibitor,analogue,trimethoprim,Brodimoprim,negative bacteria,Ro 0,Bacterial,am 5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine 5-(4-Bromo-3,5-dimethoxybenzyl)pyrimidine-2,4-diamine brodimoprim HypriM 5-[(4-bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine 5-(4-BroMo-3,5-diMethoxybenzyl)-2,4-pyriMidinediaMine 5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine EINECS 260-238-8 Benzenesulfonicacid,8-(bromomethyl) Bromidoprim 5-(3,5-dimethoxy-4-bromobenzyl)-2,4-diaminopyrimidine 2,4-Pyrimidinediamine, 5-[(4-bromo-3,5-dimethoxyphenyl)methyl] 5-(3,5-Dimethoxy-4-bromobenzyl)-2,4-pyrimidinediamine Bromodiprim 5-((4-bromo-3,5-dimethoxyphenyl)methyl)-4-pyrimidinediamine Ro-10-5970 bromdimoprim Bromopropyl 5-((4-bromo-3,5-dimethoxyphenyl)methyl)-2,4-pyrimidinediamine UnitriM Fulvestrant Impurity 54 Hyprim：Unitrim 5-(4-Bromo-3,5-dimethoxybenzyl)-2,4-pyrimidinediamine Brodimoprim //BP

Description	Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Weidekamm E. Pharmacokinetics of brodimoprim. J Chemother. 1993;5(6):475-479. [2]. Marchese A, et al. Brodimoprim: effects of subminimal inhibitory concentrations on virulence traits of respiratory and urinary tract pathogens, and on plasmid transfer and stability. J Chemother. 1996;8(3):171-177.

Density	1.5±0.1 g/cm3
Boiling Point	563.8±60.0 °C at 760 mmHg
Melting Point	225-228°
Molecular Formula	C₁₃H₁₅BrN₄O₂
Molecular Weight	339.19
Flash Point	294.7±32.9 °C
Exact Mass	338.037842
PSA	96.28000
LogP	1.43
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.646

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8139340

CHEMICAL NAME :: 2,4-Pyrimidinediamine, 5-((4-bromo-3,5-dimethoxyphenyl)methyl)-

CAS REGISTRY NUMBER :: 56518-41-3

BEILSTEIN REFERENCE NO. :: 0760113

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C13-H15-Br-N4-O2

MOLECULAR WEIGHT :: 339.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2514 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3724 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 147 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1054 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13650 mg/kg/13W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1040 mg/kg/13W-C

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

Hazard Codes	Xn
HS Code	2933599090

Precursor 0
DownStream 1
96103-67-2

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

74545-28-1	18251-41-7
25576-14-1	96619-95-3
15087-42-0	1245644-57-8
2964-65-0	103986-83-0
41740-34-5	114353-21-8