Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Antibiotic 1142
Price: ￥3478.0/25mg ￥1058.0/5mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Antibiotic 1142
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1438-30-8

1438-30-8 structure

1438-30-8 structure

Name: Antibiotic 1142
Chemical Name: netropsin
CAS Number: 1438-30-8
Molecular Formula: C₁₈H₂₆N₁₀O₃
Molecular Weight: 430.46400
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-07-24 07:11:55
Modify Date: 2024-01-03 11:50:10
Netropsin is a basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research. Netropsin is a polyamide with antibiotic and antiviral activity. It has been shown that Netropsin is active both against Gram-positive bacteria and Gram-negative bacteria.

Name	netropsin
Synonyms	4-{4-[(N-carbamimidoyl-glycyl)-amino]-1-methyl-pyrrole-2-carbonylamino}-1-methyl-pyrrole-2-carboxylic acid-(2-carbamimidoyl-ethylamide) t1384 Netropsin dihydrochloride ia887 4-{4-[(N-Carbamimidoyl-glycyl)-amino]-1-methyl-pyrrol-2-carbonylamino}-1-methyl-pyrrol-2-carbonsaeure-(2-carbamimidoyl-aethylamid) ch-777-a Congocidin Sinanomycin congocidin ultrapuregrade 2814-a antibiotic1142

Density	1.52g/cm3
Boiling Point	544.74°C (rough estimate)
Melting Point	171-173℃
Molecular Formula	C₁₈H₂₆N₁₀O₃
Molecular Weight	430.46400
Exact Mass	430.21900
PSA	208.93000
LogP	1.62120
Appearance	powder \| faint yellow
Vapour Pressure	1.75E-23mmHg at 25°C
Index of Refraction	1.6500 (estimate)
Storage condition	−20°C
Water Solubility	H2O: 1 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW2973000

CHEMICAL NAME :: N,4'-Bi(pyrrole-2-carboxamide), N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amin o)-1,1'- dimethyl-

CAS REGISTRY NUMBER :: 1438-30-8

BEILSTEIN REFERENCE NO. :: 0376913

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H26-N10-O3

MOLECULAR WEIGHT :: 430.54

WISWESSER LINE NOTATION :: T5NJ A1 BVM2VZ EMV- BT5NJ A1 DMYUM&1MYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: MLBRBU Molecular Biology Reports. (Dr. W. Junk Pub., POB 163, 3300 AD Dordrect, Netherlands) V.1- 1973- Volume(issue)/page/year: 2,135,1975

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	DW2973000