292171-04-1

292171-04-1 structure

Name: Ac-Pro-Gly-Pro-OH
Chemical Name: Ac-Pro-Gly-Pro-OH
CAS Number: 292171-04-1
Molecular Formula: C₁₄H₂₁N₃O₅
Molecular Weight: 311.33
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2016-01-09 04:02:13
Modify Date: 2025-08-25 19:12:23
Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].

Name	Ac-Pro-Gly-Pro-OH
Synonyms	ABCB1 N-acetyl-proline-glycine-proline AcPGP MDR1 HUMAN MEMBRANE PREPARATION PGP Ac-PGP trifluoroacetate salt hydrate

Description	Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR2
References	[1]. Patel DF, et al The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017. [2]. Kim SD, et al. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011 Jul 15;184(2):243-51.