Ac-Pro-Gly-Pro-OH

Modify Date: 2025-08-25 19:12:23

Ac-Pro-Gly-Pro-OH Structure
Ac-Pro-Gly-Pro-OH structure
Common Name Ac-Pro-Gly-Pro-OH
CAS Number 292171-04-1 Molecular Weight 311.33
Density N/A Boiling Point N/A
Molecular Formula C14H21N3O5 Melting Point N/A
MSDS USA Flash Point N/A

 Use of Ac-Pro-Gly-Pro-OH


Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].

 Names

Name Ac-Pro-Gly-Pro-OH
Synonym More Synonyms

 Ac-Pro-Gly-Pro-OH Biological Activity

Description Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].
Related Catalog
Target

CXCR2

References

[1]. Patel DF, et al The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017.  

[2]. Kim SD, et al. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011 Jul 15;184(2):243-51.  

 Chemical & Physical Properties

Molecular Formula C14H21N3O5
Molecular Weight 311.33
Exact Mass 311.14800
PSA 107.02000

 Synonyms

ABCB1
N-acetyl-proline-glycine-proline
AcPGP
MDR1 HUMAN MEMBRANE PREPARATION
PGP
Ac-PGP trifluoroacetate salt hydrate
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