95927-67-6
95927-67-6 structure
- Name: Swinholide A
- Chemical Name: swinholide a
- CAS Number: 95927-67-6
- Molecular Formula: C78H132O20
- Molecular Weight: 1389.87
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2017-12-13 05:53:55
- Modify Date: 2024-01-02 18:23:17
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Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM[1]. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity[2].
| Name | swinholide a |
|---|---|
| Synonyms |
isostearic acid N
MFCD01861928 isostearoyl chloride isoswinholide A |
| Description | Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM[1]. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Swinholide A, first isolated from the Okinawan marine sponge Theonella swinhoei, dimerizes actin[1]. Swinholide A, isolated from the marien sponge Theonella swinhoei, is highly cytotoxic to a variety of cancer cell lines[2]. Swinholide A disrupts the actin cytoskeleton of cells grown in culture, sequesters actin dimers in vitro in both polymerizing and non-polymerizing buffers with a binding stoichiometry of one swinholide A molecule per actin dimer, and rapidly severs F-actin in vitro with high cooperativity[2]. Cell Viability Assay[2] Cell Line: Balb/c 3T3 and Swiss 3T3 cells Concentration: 5-100 nM Incubation Time: 1-24 h Result: Exponentially growing cells exposed to 10 nM for 24 h became arborized with diffuse cytoplasmic staining and fluorescent punctate structures. Partial cell retraction or arborization and diminution of microfilament bundles began after 2-4 h, with complete loss of stress fibers by 5-7 h at concentrations of 10-50 nM. Caused rounding of cultured mouse embryo 3T3 fibroblast cells within 1 h at concentration of 80 nM. |
| References |
| Density | 1.15 g/cm3 |
|---|---|
| Boiling Point | 1249.8ºC at 760 mmHg |
| Molecular Formula | C78H132O20 |
| Molecular Weight | 1389.87 |
| Flash Point | 307.3ºC |
| Exact Mass | 1388.93000 |
| PSA | 288.28000 |
| LogP | 9.96570 |
| Index of Refraction | 1.549 |
|
~43%
95927-67-6 |
| Literature: Paterson, Ian; Yeung, Kap-Sun; Ward, Richard A.; Cumming, John G.; Smith, Julian D. Journal of the American Chemical Society, 1994 , vol. 116, # 20 p. 9391 - 9392 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |