CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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BY6300000
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CHEMICAL NAME :
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Aniline, N-methyl-N,2,4,6-tetranitro-
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CAS REGISTRY NUMBER :
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479-45-8
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BEILSTEIN REFERENCE NO. :
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0964788
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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31
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MOLECULAR FORMULA :
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C7-H5-N5-O8
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MOLECULAR WEIGHT :
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287.17
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WISWESSER LINE NOTATION :
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WNN1&R BNW DNW ENW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5 gm/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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5 gm/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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5 gm/kg
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TOXIC EFFECTS :
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Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in both tubules and glomeruli Kidney, Ureter, Bladder - interstitial nephritis
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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>2 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5580 mg/kg/90D-C
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TOXIC EFFECTS :
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Blood - other changes Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
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TYPE OF TEST :
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Gene conversion and mitotic recombination
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TEST SYSTEM :
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Yeast - Saccharomyces cerevisiae
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REFERENCE :
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TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 5,11,1980 *** REVIEWS *** ACGIH TLV-TWA 1.5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,255,1971 OSHA PEL (Gen Indu):8H TWA 1.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1.5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 1.5 mg/m3 JAN 1993 OEL-DENMARK:TWA 1.5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 1.5 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 1.5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 15 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 1.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 1.5 mg/m3;Skin JAN 1993 OEL-TURKEY:TWA 1.5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TETRYL-air:10H TWA 1.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
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