367927-39-7
367927-39-7 structure
- Name: SMPH Crosslinker
- Chemical Name: N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate
- CAS Number: 367927-39-7
- Molecular Formula: C17H21N3O7
- Molecular Weight: 379.36500
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-10-23 08:28:11
- Modify Date: 2026-07-01 22:05:05
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SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate |
|---|---|
| Synonyms |
6-(3-Maleimidopropionylamino)-hexanoic acid-NHS ester
N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate（SMPH Crosslinker） N-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-1-propanamide Succinimidyl-6-[(β-maleimidopropionamido)hexanoate Hexanoic acid, 6-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester N-SUCCINIMIDYL 6-(3-MALEIMIDOPROPIONAMIDO) HEXANOATE (2,5-dioxopyrrolidin-1-yl) 6-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]hexanoate 6-(N-[3-MALEIMIDOPROPIONAMIDO])HEXANOATE-SUCCINIMIDE SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate)) 6-[[3-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]hexanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester |
| Description | SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C17H21N3O7 |
|---|---|
| Molecular Weight | 379.36500 |
| Exact Mass | 379.13800 |
| PSA | 130.16000 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
