148067-21-4

148067-21-4 structure

Name: Calcineurin autoinhibitory peptide
Chemical Name: Calcineurin autoinhibitory fragment
CAS Number: 148067-21-4
Molecular Formula: C₁₂₄H₂₀₅N₃₉O₃₉S₂
Molecular Weight: 2930.32000
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2018-10-11 09:32:18
Modify Date: 2025-08-23 18:50:58
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].

Name	Calcineurin autoinhibitory fragment
Synonyms	ITSFEEAKGLDRINERMPPRRDAMP Calcineurin autoinhibitory peptide

Description	Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Neurological Disease
Target	IC50: ~10 μM (calcineurin)[1]
References	[1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7. [2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.

Hazard Codes	Xi
WGK Germany	3.0