623166-14-3

623166-14-3 structure

Name: JYL-1511
Chemical Name: 1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)-3-methoxyphenyl]methyl]thiourea
CAS Number: 623166-14-3
Molecular Formula: C₂₁H₂₉N₃O₃S₂
Molecular Weight: 435.60
Create Date: 2017-04-20 17:18:36
Modify Date: 2024-04-14 11:25:31
JYL 1511 is a partial agonist of vanilloid receptor VR1[1].

Name	1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)-3-methoxyphenyl]methyl]thiourea
Synonyms	JYL-1511 Methanesulfonamide,N-(4-((((((4-(1,1-dimethylethyl)phenyl)methyl)amino)thioxomethyl)amino)methyl)-2-methoxyphenyl) thiourea analogue,3 UNII-9MD3654O9N

Description	JYL 1511 is a partial agonist of vanilloid receptor VR1[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Inflammation/Immunology
In Vitro	JYL 1511 抑制 [3H]Resiniferatoxin 与大鼠 VR1 的结合，Ki 为 50.4 nM[1]。 JYL 1511 抑制过表达大鼠 VR1 的 CHO 细胞中辣椒素诱导的 45Ca2+ 摄取 (IC50: 3.4 nM)[1].
References	[1]. Wang Y, et al. High-affinity partial agonists of the vanilloid receptor. Mol Pharmacol. 2003 Aug;64(2):325-33.