JYL-1511

Modify Date: 2024-04-14 11:25:31

JYL-1511 Structure
JYL-1511 structure
Common Name JYL-1511
CAS Number 623166-14-3 Molecular Weight 435.60
Density N/A Boiling Point N/A
Molecular Formula C21H29N3O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JYL-1511


JYL 1511 is a partial agonist of vanilloid receptor VR1[1].

 Names

Name 1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)-3-methoxyphenyl]methyl]thiourea
Synonym More Synonyms

 JYL-1511 Biological Activity

Description JYL 1511 is a partial agonist of vanilloid receptor VR1[1].
Related Catalog
In Vitro JYL 1511 抑制 [3H]Resiniferatoxin 与大鼠 VR1 的结合,Ki 为 50.4 nM[1]。 JYL 1511 抑制过表达大鼠 VR1 的 CHO 细胞中辣椒素诱导的 45Ca2+ 摄取 (IC50: 3.4 nM)[1].
References

[1]. Wang Y, et al. High-affinity partial agonists of the vanilloid receptor. Mol Pharmacol. 2003 Aug;64(2):325-33.  

 Chemical & Physical Properties

Molecular Formula C21H29N3O3S2
Molecular Weight 435.60
Exact Mass 435.16500
PSA 119.93000
LogP 5.46410

 Synonyms

JYL-1511
Methanesulfonamide,N-(4-((((((4-(1,1-dimethylethyl)phenyl)methyl)amino)thioxomethyl)amino)methyl)-2-methoxyphenyl)
thiourea analogue,3
UNII-9MD3654O9N
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