92953-10-1
92953-10-1 structure
- Name: Clofilium tosylate
- Chemical Name: 4-(4-chlorophenyl)butyl-diethyl-heptylazanium,4-methylbenzenesulfonate
- CAS Number: 92953-10-1
- Molecular Formula: C28H44ClNO3S
- Molecular Weight: 510.172
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2018-06-27 02:26:43
- Modify Date: 2024-01-02 19:28:43
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Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent[1].
| Name | 4-(4-chlorophenyl)butyl-diethyl-heptylazanium,4-methylbenzenesulfonate |
|---|---|
| Synonyms |
N-[4-(4-Chlorophenyl)butyl]-N,N-diethyl-1-heptanaminium 4-methylbenzenesulfonate
Benzenebutanaminium,4-chloro-N,N-diethyl-N-heptyl-,salt with 4-methylbenzenesulfonicacid (1:1) 4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium tosylate Clofilium tosylate Prestwick_682 |
| Description | Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent[1]. |
|---|---|
| Related Catalog | |
| Target |
Potassium channel[1] |
| In Vitro | HL-60 cells treated with Clofilium (0-20 μM; 24, 48, and 72 hours) lead to suppression of viability and proliferation in both time and concentration-dependent manners. Cell viability decreases significantly in HL-60 cells treated with 2.5 μM to 10 μM of Clofilium[1]. Clofilium (10 μM, 12 hours) induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP at 2 h after exposure to 10 mM Clofilium. However, there is no significant change in expression of Bcl-2 and Bax proteins[1]. Cell Viability Assay[1] Cell Line: HL-60 cells Concentration: 0-20 μM Incubation Time: 24, 48, and 72 hours Result: Inhibited HL-60 cells with IC50s of 6.3 μM for 24 hours, 3.4 μM for 48 hours, 2.4 μM for 72 hours, respectively. Western Blot Analysis[1] Cell Line: HL-60 cells Concentration: 10 μM Incubation Time: 12 hours Result: Induced proteolytic cleavage of caspase-3 and subsequent cleavage of its substrate, PARP, while Bcl-2 and Bax proteins were unaltered. |
| References |
| Molecular Formula | C28H44ClNO3S |
|---|---|
| Molecular Weight | 510.172 |
| Exact Mass | 509.273041 |
| PSA | 65.58000 |
| LogP | 8.46960 |
| Storage condition | 2-8℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| RTECS | CY9040870 |