32140-51-5

32140-51-5 structure

Name: Acetyl coenzyme A lithium
Chemical Name: trilithium,[(2R,3S,4R,5R)-2-[[[[(3R)-4-[[3-(2-acetylsulfanylethylamino)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-3-yl] hydrogen phosphate
CAS Number: 32140-51-5
Molecular Formula: C₂₃H₃₅Li₃N₇O₁₇P₃S
Molecular Weight: 827.37000
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-03-04 08:00:00
Modify Date: 2024-01-09 12:14:48
Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis[1][2][3][4].

Name	trilithium,[(2R,3S,4R,5R)-2-[[[[(3R)-4-[[3-(2-acetylsulfanylethylamino)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-3-yl] hydrogen phosphate
Synonyms	Acetyl-S-CoA Li3 acetyl-CoA Acetyl coenzyme A lithium salt Lithiumacetyl-CoA

Description	Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis[1][2][3][4].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Acetyl coenzyme A lithium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A lithium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h)[2].
In Vivo	Acetyl coenzyme A lithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy[2][3].Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A lithium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A lithium concentrations in the brain and actually increase hepatic Acetyl coenzyme A lithium and protein acetylation levels[4].
References	[1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50. [2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25. [3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93. [4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

Molecular Formula	C₂₃H₃₅Li₃N₇O₁₇P₃S
Molecular Weight	827.37000
Exact Mass	827.15000
PSA	426.85000
LogP	1.36220
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport

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