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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Vinleurosine
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23360-92-1

23360-92-1 structure

23360-92-1 structure

Name: vinleurosine
Chemical Name: leurosine
CAS Number: 23360-92-1
Molecular Formula: C₄₆H₅₆N₄O₉
Molecular Weight: 808.96
Create Date: 2018-09-17 15:32:12
Modify Date: 2026-07-16 10:14:03
Vinleurosine is an indole alkaloid with antineoplastic activity[1].

Name	leurosine
Synonyms	Vincristine Impurity F (Leurosine) Vinorelbine Impurity E/Leurosine/4b-Acetoxy-3,4oxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester Vincristine Impurity F(Vinorelbine Impurity E) amotin Vincaleukoblastine, 4'-deoxy-3',4'-oxy-, (3'α,4'α) Vincaleukoblastine,4'-deoxy-3',4'-oxy-, (3'a,4'a) (2'β,4'α,5'α)-O',5'-Cyclovincaleukoblastine 4’-deoxy-3’,4’-oxy-,(3’-alpha,4’-alpha)-vincaleukoblastin Vinleurosine (3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine (1aS,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-ethyl-2,4,5,10,11,12,13,13a-octahydro-1aH-3,13-methanooxireno[2',3':9,10]azacycloundecino[5,4-b]indole-11-cboxylate 4′-deoxy-3′α,4′α-oxyvincaleukoblastine(leurosine) 4b-Acetoxy-3,4oxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester LEUROSINE methyl(3,4R,5S,5,10bR,13-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13-1a-ethyl-11-(methoxycbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]cbazole-5-cboxylate(leurosine) (1aS,11S,13S,13-methyl 11-((3,3a1R,4R,5S,5,10bR)-4-acetoxy-3a-ethyl-5-hydroxy-8-methoxy-5-(methoxycbonyl)-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]cbazol-9-yl)-1a-ethyl nsc-528004 Vincristine Impurity 6(Vincristine Impurity F) 4’-deoxy-3’,4’-oxy-,(3’alpha,4’alpha)-vincaleukoblastin 4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester (3'alpha,4'alpha)-4'-Deoxy-3',4'-oxyvincaleukoblastine (2'β,3'β)-O',3'-Cyclovincaleukoblastine 4'-Deoxy-3',4'-epoxyvincaleucoblastine,9CI Vincristine Impurity F 4'-Deoxy-3',4'-oxyvincaleucoblastine, 9CI

Description	Vinleurosine is an indole alkaloid with antineoplastic activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. W A Creasey, et al. Biochemical effects of the Vinca alkaloids. IV. Studies with vinleurosine. Biochem Pharmacol. 1969 Jan;18(1):227-32.

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₆H₅₆N₄O₉
Molecular Weight	808.96
Exact Mass	808.404724
PSA	146.40000
LogP	4.08
Index of Refraction	1.678

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OH6370000

CHEMICAL NAME :: Leurosine

CAS REGISTRY NUMBER :: 23360-92-1

BEILSTEIN REFERENCE NO. :: 0079636

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C46-H56-N4-O9

MOLECULAR WEIGHT :: 809.06

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15200 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

REFERENCE :: EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg/30D-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death

REFERENCE :: EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30 mg/kg/15D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - changes in leukocyte (WBC) count Related to Chronic Data - death

REFERENCE :: EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987

RIDADR	UN 1544
Packaging Group	II
Hazard Class	6.1(a)

Precursor 7
60706-86-7 38390-45-3 2182-14-1 26251-91-2
62028-18-6 60706-84-5 2468-21-5
DownStream 1
54022-49-0

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