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34148-01-1

34148-01-1 structure
34148-01-1 structure
  • Name: Clidanac
  • Chemical Name: Clidanac
  • CAS Number: 34148-01-1
  • Molecular Formula: C16H19ClO2
  • Molecular Weight: 278.77400
  • Catalog: API Antipyretic analgesics Analgesic
  • Create Date: 2018-03-25 08:00:00
  • Modify Date: 2024-01-09 11:31:42
  • Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis[1].
Name Clidanac
Synonyms (+-)-6-Chlor-5-cyclohexyl-1-indancarbonsaeure
1H-Indene-1-carboxylic acid,6-chloro-5-cyclohexyl-2,3-dihydro-(9ci)
6-chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid
6-Chloro-5-cyclohexyl-1-indancarboxylic acid
Britai
6-chloro-5-cyclohexylindan-1-carboxylic acid
Indanal
(+-)-6-Chlor-5-cyclohexylindan-1-carbonsaeure
Description Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis[1].
Related Catalog
In Vitro Clidanac can uncouple the oxidative phosphorylation and no difference in the uncoupling potency of the two enantiomorphs[1].
Density 1.244g/cm3
Boiling Point 424.4ºC at 760mmHg
Molecular Formula C16H19ClO2
Molecular Weight 278.77400
Flash Point 210.5ºC
Exact Mass 278.10700
PSA 37.30000
LogP 4.50210
Index of Refraction 1.587

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK4503000
CHEMICAL NAME :
1-Indancarboxylic acid, 6-chloro-5-cyclohexyl-
CAS REGISTRY NUMBER :
34148-01-1
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C16-H19-Cl-O2
MOLECULAR WEIGHT :
278.80
WISWESSER LINE NOTATION :
L56T&J BVQ HG G- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,1297,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
62700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
88400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
825 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
212 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982
HS Code 2916399090
38240-91-4 structure

38240-91-4

~%

34148-01-1 structure

34148-01-1

Literature: Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372
34177-35-0 structure

34177-35-0

~%

34148-01-1 structure

34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937
27634-89-5 structure

27634-89-5

~%

34148-01-1 structure

34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937
38913-05-2 structure

38913-05-2

~%

34148-01-1 structure

34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937
31861-70-8 structure

31861-70-8

~%

34148-01-1 structure

34148-01-1

Literature: Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536
31962-03-5 structure

31962-03-5

~%

34148-01-1 structure

34148-01-1

Literature: Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536
52487-42-0 structure

52487-42-0

~%

34148-01-1 structure

34148-01-1

Literature: Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372
HS Code 2916399090
Summary 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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