Clidanac

Modify Date: 2024-01-09 11:31:42

Clidanac Structure
Clidanac structure
Common Name Clidanac
CAS Number 34148-01-1 Molecular Weight 278.77400
Density 1.244g/cm3 Boiling Point 424.4ºC at 760mmHg
Molecular Formula C16H19ClO2 Melting Point N/A
MSDS N/A Flash Point 210.5ºC

 Use of Clidanac


Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis[1].

 Names

Name Clidanac
Synonym More Synonyms

 Clidanac Biological Activity

Description Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis[1].
Related Catalog
In Vitro Clidanac can uncouple the oxidative phosphorylation and no difference in the uncoupling potency of the two enantiomorphs[1].

 Chemical & Physical Properties

Density 1.244g/cm3
Boiling Point 424.4ºC at 760mmHg
Molecular Formula C16H19ClO2
Molecular Weight 278.77400
Flash Point 210.5ºC
Exact Mass 278.10700
PSA 37.30000
LogP 4.50210
Index of Refraction 1.587

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK4503000
CHEMICAL NAME :
1-Indancarboxylic acid, 6-chloro-5-cyclohexyl-
CAS REGISTRY NUMBER :
34148-01-1
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C16-H19-Cl-O2
MOLECULAR WEIGHT :
278.80
WISWESSER LINE NOTATION :
L56T&J BVQ HG G- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,1297,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
62700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
88400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
825 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
212 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,668,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,217,1982

 Safety Information

HS Code 2916399090

 Synthetic Route

~%

Clidanac Structure

Clidanac

CAS#:34148-01-1

Literature: Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372

~%

Clidanac Structure

Clidanac

CAS#:34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

~%

Clidanac Structure

Clidanac

CAS#:34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

~%

Clidanac Structure

Clidanac

CAS#:34148-01-1

Literature: Allen Jr.; Littell; McEvoy; Sloboda Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 934 - 937

~%

Clidanac Structure

Clidanac

CAS#:34148-01-1

Literature: Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536

~%

Clidanac Structure

Clidanac

CAS#:34148-01-1

Literature: Noguchi; Kishimoto; Minamida; Obayashi Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 529 - 536

~%

Clidanac Structure

Clidanac

CAS#:34148-01-1

Literature: Hurusawa, Shinya; Nakamura, Shuji; Yagi, Sayoko; Kurihara, Takushi; Hamada, Yasumasa; Shioiri, Takayuki Synthetic Communications, 1984 , vol. 14, # 14 p. 1365 - 1372

 Customs

HS Code 2916399090
Summary 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

(+-)-6-Chlor-5-cyclohexyl-1-indancarbonsaeure
1H-Indene-1-carboxylic acid,6-chloro-5-cyclohexyl-2,3-dihydro-(9ci)
6-chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid
6-Chloro-5-cyclohexyl-1-indancarboxylic acid
Britai
6-chloro-5-cyclohexylindan-1-carboxylic acid
Indanal
(+-)-6-Chlor-5-cyclohexylindan-1-carbonsaeure