- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 4,4'-Dimethoxybenzil
- Price:
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 4,4'-Dimethoxybenzil
- Price: ￥118.0/5g ￥338.0/25g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
1226-42-2
1226-42-2 structure
- Name: 4,4'-Dimethoxybenzil
- Chemical Name: 4,4'-Dimethoxybenzil
- CAS Number: 1226-42-2
- Molecular Formula: C16H14O4
- Molecular Weight: 270.28000
- Catalog: Chemical reagent Organic reagent Aromatic ketone
- Create Date: 2018-07-06 17:02:08
- Modify Date: 2024-01-02 21:34:41
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4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.
| Name | 4,4'-Dimethoxybenzil |
|---|---|
| Synonyms |
4,4′-Dimethoxybenzil
MFCD00008405 EINECS 214-960-5 4,4‘-Dimethoxybenzil 1,2-bis(4-methoxyphenyl)ethane-1,2-dione |
| Description | 4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM. |
|---|---|
| Related Catalog | |
| Target |
Ki: 70 nM (hiCE)[1] |
| In Vitro | By reducing irinotecaninduced diarrhea, hiCE inhibitors (e.g., 4,4'-Dimethoxybenzil, Compound 8) can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed[1]. |
| References |
| Density | 1.183g/cm3 |
|---|---|
| Boiling Point | 442.2ºC at 760 mmHg |
| Melting Point | 132-134ºC(lit.) |
| Molecular Formula | C16H14O4 |
| Molecular Weight | 270.28000 |
| Flash Point | 197.5ºC |
| Exact Mass | 270.08900 |
| PSA | 52.60000 |
| LogP | 2.76940 |
| Vapour Pressure | 5.13E-08mmHg at 25°C |
| Index of Refraction | 1.566 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 22-24/25-36/37-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2914509090 |
| Precursor 9 | |
|---|---|
| DownStream 10 | |
![1-methoxy-4-[2-(4-methoxyphenyl)ethynyl]benzene structure](https://image.chemsrc.com/caspic/247/2132-62-9.png)
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |