DC Chemicals Limited
China
Product Name: Methopterin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2410-93-7

2410-93-7 structure

Name: 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid
Chemical Name: L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
CAS Number: 2410-93-7
Molecular Formula: C₂₀H₂₁N₇O₆
Molecular Weight: 455.42400
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2017-09-10 00:17:59
Modify Date: 2024-01-14 10:40:47
Methopterin inhibits osteoclasts proliferation. Methopterin inhibits the activation and bone resorption function of osteoclasts, and induced osteoclasts apoptosis[1].

Name	L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
Synonyms	N-[p-[[(2-AMino-4-hydroxy-6-pteridinyl)Methyl]MethylaMino]benzoyl]glutaMic Acid N(10)-methylfolate N-(10-methyl-pteroyl)-L-glutamic acid N-[4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid Methotrexate impurity C 10-Methylpteroylglutamic acid N10-methylfolic acid N10-MethylpteroylglutaMic Acid N-[p-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid 1-methylfolic acid N-(10-Methyl-pteroyl)-L-glutaminsaeure 10-methylpteroylglutamlic acid N-[4-[Methyl(2-amino-4-hydroxypteridine-6-ylmethyl)amino]benzoyl]glutamic acid 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid

Description	Methopterin inhibits osteoclasts proliferation. Methopterin inhibits the activation and bone resorption function of osteoclasts, and induced osteoclasts apoptosis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Li P, et al. [Effects of methopterin on osteoclasts and study of its mechanism of action]. Yao Xue Xue Bao. 2008 Oct;43(10):1025-31.

Density	1.61g/cm3
Molecular Formula	C₂₀H₂₁N₇O₆
Molecular Weight	455.42400
Exact Mass	455.15500
PSA	204.75000
LogP	1.36390
Index of Refraction	1.732

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0700000

CHEMICAL NAME :: Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridyl)methyl)methylami no)benzoyl)-

CAS REGISTRY NUMBER :: 2410-93-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N7-O6

MOLECULAR WEIGHT :: 455.48

WISWESSER LINE NOTATION :: T66 BN DN GN JNJ CZ EQ H1NVR D1Z&YVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,688,1955

RIDADR	NONH for all modes of transport

59-05-2

~80%

2410-93-7

Literature: Charlton, Peter A.; Young, Douglas W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1363 - 1370