CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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CU3350000
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CHEMICAL NAME :
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Benz(c)acridine-7-carboxylic acid, 5,6-dihydro-
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CAS REGISTRY NUMBER :
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83-93-2
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BEILSTEIN REFERENCE NO. :
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0256492
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LAST UPDATED :
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199709
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DATA ITEMS CITED :
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3
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MOLECULAR FORMULA :
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C18-H13-N-O2
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MOLECULAR WEIGHT :
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275.32
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WISWESSER LINE NOTATION :
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T D6 C666 BN&T&&J MVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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760 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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40 mg/kg
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TOXIC EFFECTS :
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Vascular - BP lowering not characterized in autonomic section
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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40 mg/kg
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TOXIC EFFECTS :
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Behavioral - tetany Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,371,1955
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